Benzathine benzylpenicillin: inkcazelo, iimpawu kunye isicelo, analogs

Benzathine Benzylpenicillin yi-zintsholongwane kwaye lol kwiqela penicillin kulo. Asetyenziselwa ukunyanga zonke iintlobo zezifo ezosulelayo ezibangelwa iintsholongwane bangenwe wesenzo. Kweli nqaku siza ngokweenkcukacha imiyalelo ukusetyenziswa, kubonakala kunye Izimo ukuba ichiza, ngokunjalo uluhlu oontanga ezimbalwa.

Benzathine benzylpenicillin: inkcazelo ichiza

Eli chiza lelinye iqela lokuqala antibiotics penicillin. Nangona isicelo ixesha elide kakhulu, iye bungalahleki kwesinomhlwa ukufaneleka ngenxa uluhlu olubanzi izenzo kunye nokukwazi ukubulala ezahlukeneyo iintsholongwane izifo. Ichiza, umzekelo, unako ukumelana anthrax, meningococci, negcushuwa kunye nobuninzi streptococci kunye staphylococci. Ngaba zifakwa njengoko kwisiqwenga kokudla kwelifunekayo benzathine benzylpenicillin.

Indlela e Latin kudla kumiselwe ngoogqirha, kwaye ke isigulane kunzima ukuqonda oko wanikwa. Ukuze uphephe oku isiphithiphithi, kufuneka nje wazi igama beziyobisi kolu lwimi - Benzathine benzylpenicillinum.

Ngokuqhelekileyo, ichiza ilawulwa yegazi okanye intramuscularly. Kodwa kusenokwenzeka kunye neziyobisi unikezelo kwi emzimbeni emjelweni spinal, kwesikhumba okanye kummandla ochaphazelekayo.

Benzylpenicillin - zintsholongwane yabhalwa iziyobisi enye esebenzayo. Kodwa ungena ichiza ngokohlobo neetyuwa. Ngoko ke into nga ugcinwe ixesha elide ngaphandle kokonakalisa phantsi. Kwaye emva kokuba ukuqaliswa penicillin G iphume emzimbeni neetyuwa kwaye iqala wesenzo antibacterial.

Kuxhomekeka indlela apho ityuwa i into esebenzayo, iindidi ezininzi amayeza. Ngaphandle koku, bonke baye malunga neziphumo ezifanayo, kunye neendlela ezahlukeneyo zolawulo kunye nobude isiphumo.

ubungqina

Benzathine benzylpenicillin omiselwe zifo zilandelayo:

• Izifo amalungu nokuphefumla (unepleurisy, inyumoniya, iphika, empyema , njalo njalo.).
• Izifo kwenkqubo genitourinary (negcushuwa, ukuvuza ngaphantsi, urethritis, Ngokuzimela, adnexitis, salpingitis).
• Izifo Kwiphecana zangentla ezihlasela zosulele ngokuphefumla (ngumkhuhlane nebomvu, tonsils, sinusitis, amajelo otitis, sinusitis, laryngitis, njalo njalo).
• izifo ubovu amalungu ezibonwayo, amathambo kunye ulusu, inwebu yangaphakathi (ophthalmia, dacryocystitis, blepharitis, osteomyelitis, mediastinitis, erysipelas, cellulitis, usulelo nxeba, njalo njalo.).
• Brain ithumba.
• Ubovu meningitis.
• Septicemia, nokudumba.
• Samathambo.
• Peritonitis.
• Izifo ezibangelwa spirochetes (yaws, anthrax, njalo njalo).
• Fever okubangelwa ibuzi ukuluma.
• Izifo ezibangelwa Listeria, zeClostridium, nePasteurella.

Ngaphezu koko, ichiza elo lilawulwa iingxaki prophylactically postoperative kunye neengxaki kunye usuleleko streptococcal (endocarditis, samathambo, glomerulonephritis njalo njalo.).

Pharmacokinetics

Benzathine benzylpenicillin (Latin Benzathine benzylpenicillinum) ngoko nangoko emva ulawulo luqala ukuba iba, ukhupha izinto esebenzayo. Ngelo xesha elinye ichiza ihlala egazini kwiiveki 3 elandelayo emva kokuba isitofu. Le into engamanzi ingena ngcono kakhulu kunaleyo kwithishyu. Kufuneka ikhunjulwa into yokuba benzyl penicillin uyakwazi onokuwoyisa ngayo umqobo placental ifakwe ubisi lomama abalupheleyo. Kwazona ngokusebenzisa izintso ngohlobo ingaguqukanga. Kwiintsuku zokuqala 8 yakhululwa malunga-33% ye idosi elawulwa.

Ukukhulelwa wamabele-lwebele

Njengokuba sele sitshilo, ichiza uyakwazi ukungena ngumkhaya kwaye angene ubisi lwebele. Ngoko ke, ibele kufuneka kupheliswa xa kulawulo ichiza.

Ngexa lokukhulelwa, ukuqeshwa ichiza kunokwenzeka kuphela xa inzuzo kubafazi mkhulu ngaphezu ezingozini umntwana. Isigqibo kufuneka senziwe gqirha, isilumkiso unina elizayo yonke imiphumo kunokwenzeka.

Izimo

Benzathine benzylpenicillin (iresiphi angamisela ugqirha) kukho inani Izimo. Kumele ukuba kumiselwe kubantu zigulo zilandelayo:

• Ukunganyamezelani penicillin okanye cephalosporin, i uxabane kubo.
• Inqanaba eliphezulu potassium egazini (hyperkalaemia).
• Arrhythmia.
• Hay fever.
• somoya inyumoniya.
• insufficiency kwezintso.
• besisu Pseudomembranous.

Amanyathelo medicament elawulwa abantwana ukuya kwiinyanga ezintandathu ngaphambi kwexesha.

imiphumela emibi

Benzathine benzylpenicillin kungabangela ezinye iziphumo ezingafunekiyo, zibhale apha ngezantsi.

ukusabela Various komzimba:

• umkhuhlane;
• ezindlwini;
• ukungxama phezu inwebu yangaphakathi kunye nesikhumba;
• ubuhlungu bamalunga;
• eosinophilia;
• erythema multiforme;
• Angioedema;
• dermatitis exfoliative;
• yashiya anaphylactic.

abasabela Ezingalunganga yenkqubo senhliziyo:

• thrombocytopenia;
• igazi;
• ukuphazamiseka coagulation;
• leukopenia.

Ukongeza:

• stomatitis;
• intloko;
• glossitis;
• iintlungu kwindawo kulawulo;
• mathumba;
• lingene;
• jade neuropathy;
• fistulas.

Nokusebenzisa elide fungi eziyingozi kunye micro-eziphilayo angaphuhlisa ukuxhathisa, ngoko ichiza ziya kuphulukana ukusebenza kwayo.

Benzathine benzylpenicillin: imiyalelo yokusebenzisa

Izigulane ezindala ngaphezu kweminyaka eli-12, eli chiza njengenyathelo zothintelo kunye nonyango kwezifo ezosulelayo ilungiselelwayo kanye ngeveki kwi umthamo 300 ukuya-600 lamawaka. Units okanye kabini ngenyanga kwiiyunithi izigidi ezi-1,2.

Njengoko amanyathelo othintelo ukuba rheumatism emnweni ngeyeza iiveki ezi-6, kanye ngeveki nakwiiyunithi 600 lamawaka. Ngelo xesha ukumisela aspirin okanye ezinye NSAIDs.

Izigulane ungaphantsi kweminyaka eyi-12, ichiza ilawulwa kanye ngeveki ngomlinganiselo 5-10 amawaka. Units nganye 1 kg.

Phakathi iinaliti kufuneka kwenzeke kwiintsuku ezingama-8. I-avareji umthamo million 2.3.

Phambi ukusetyenziswa, ichiza itshitshisiwe e yeyetyuwa, amanzi hoc ziphene ad okanye novocaine (2.5% okanye 5%).

Kwaqaliswa ichiza inokuba ngezi ndlela zilandelayo:

• intramuscular;
• emthanjeni;
• ongama;
• Empontshwa (nge emjelweni spinal);
• pleural (ngokusebenzisa pleura pulmonary);
• subconjunctival (nge ancedisana ocular);
• athontsize ngokusebenzisa indlebe;
• athontsize ngokusebenzisa empumlweni;
• ngqo organ inyama achaphazelekayo.

Kolimo namanye amachiza

Benzathine benzylpenicillin (umyalelo ngqo njengoko kubonisiwe) ukuze basebenzisane kunye nezinye iziyobisi. Ngaloo ndlela ke benzylpenicillin abe la manyathelo alandelayo: a ihambelana, bamchasa uYesu kunye bacteriostatic.

Ukongeza, ichiza kwandisa ukusebenza iziyobisi, endingowakhe anticoagulants ngqo. Yaye kunciphisa impumelelo ethinyl estradiol kunye zokucwangcisa zomlomo ezahlukeneyo.

Sebenzisa kunye NSAIDs, allopurinol, womchamo iziphumo ekuncipheni secretion tubular nokwanda lamanani esisebenza. Ukongeza, allopurinol kwandisa kakhulu umngcipheko negazi lakho.

amanyathelo okhuseleko

Ukuba phambi kokuba naliti lokuqala kuyimfuneko ukuba aspirate. Ukuba ichiza ngempazamo ingena imithambo yegazi, oku kungabangela ischemia okanye Embolism. Ukongeza, kungakhona imvakalelo ixhala, udandatheko, umbono idlule imfiliba.

Kwiimeko apho ufuna ukwenza ngesitofu emibini ngexesha, ichiza elo lilawulwa iingalo okanye ezimpundu ezahlukeneyo.

Xa wabonakala kuqala unyango komzimba kufuneka iphazanyiswe ngoko nangoko. Ngokutsho iimeko ugqirha ukubekwa amayeza komzimba.

Amaxesha amaninzi ne benzylpenicillin kumisela 'Levorinum "okanye" Nystatin ", njengoko kukho umngcipheko zizifo ezinzwaneni. Ngoko ke unyango lwexesha elide ichiza zingenzeka inhibition of microflora wamathumbu elenza iivithamini B. Kulo mba, unako kwenziwa nolawulo intramuscular ezi iivithamini.

oyi

Benzathine benzylpenicillin wabelwa isilumkiso kubaguli abaye waphawula iintlobo umsebenzi kwezintso, kukho ukuthambekela obubonakala kukwalisa, kunye uvakalelo oluphezulu ukuya isithako esebenzayo. Isigqibo sokugqibela isoloko kwamagxa igqirha, ngubani ekufuneka uyazi imbali isiguli sakhe.

Hayi Kucetyiswa kweziyobisi ngenxa yonyango neurosyphilis, ekubeni esi sifo ayikwazi kuphunyezwa ukufumaneka ezinqwenelekayo into esebenzayo igazi yesigulane.

analogs

Kukho nezinye iziyobisi neziphumo ezifanayo njengoko benzathine benzylpenicillin. Analogs, Kakade ke, nayo abe kwiqela penicillin kulo. Sibala edumileyo nolusebenzayo:

• "Gramoks-D" - lukhutshwe ngokohlobo ngumgubo ekucetywa ukuba zingazala kunye nolawulo ngomlomo.
• "Amosin" - evela njengezingxobo, iipilisi kunye olungumgubo nolawulo ngomlomo.
• "Kwakulula" - yenziwe ngohlobo isiraphu.
• "Hikontsil" - kufumaneka ngohlobo powder kunye njengezingxobo lolawulo ngomlomo.
• Azlocillin sodium ityuwa - into olungumgubo ukusuka ezenza isisombululo ukuba inaliti efakwa.
• "Ampicillin" - ifumaneka emacwecweni, njengezingxobo, granules ngasekho wenze oluludaka, kwaye kuthathwa ngomlomo.
• "Ekobol" - wavelisa iipilisi.
• "Ospamoks" - yenziwe ngohlobo amacwecwe, njengezingxobo kunye olungumgubo nolawulo ngomlomo.
• "Phenoxymethylpenicillin" - ifumaneka emacwecweni, dragees, granules kunye Ithatyathwe emigutyeni.
• "Star-Pen" - yenziwe ngohlobo granules, ezithi exutywe, kwaye ngomlomo.
• "Oxacillin" - yenziwe ngohlobo amacwecwe, njengezingxobo, ngumgubo, ukusuka apho, isisombululo ukuba isitofu.
• "Standatsillin" - ifumaneka njengezingxobo.
• Carbenicillin disodium ityuwa - lukhutshwe kwifomu olungumgubo eyimveliso sisombululo inaliti.

Ngaloo ndlela, nangona ukusetyenziswa kakhulu ixesha elide beziyobisi amayeza, nangoku uhlala enye arhente kakhulu nxamnye iintlobo zosulelo.