Amachiza Anti-estrogen: inkcazelo, isicelo

Estrogen-blocker ezi anemichiza ezithintela isenzo estrogen. iziyobisi Antiestrogen esetyenziswa ukunyanga izifo ezahlukahlukeneyo. Bona esisetyenziswa ngokubanzi kwi unyango umhlaza kweenkqubo webele ukuze kuthintelwe ukukhula ithumba okanye kuthintelo likakade. Njengoko kunjalo kunye namanye amachiza ukuba basebenzisane hormone emzimbeni, la machiza kufuneka zisetyenziswe phantsi kweliso zonyango.

Iinzuzo tywaleni estrogen

Estrogen, okanye hormone steroid kuhlelwe ikakhulu zamaqanda. Ichaphazela eziliqela iinkqubo zomzimba. Amakhosikazi yokuzala babe inqanaba eliphezulu hormone zendalo. Imali kakhulu, kunjalo, kunokubangela i syndrome eyaziwa ngokuba hyperestrogenia. Esi sifo kunokukhokelela kwinkqubo umhlaza webele umhlaza endometrial. amachiza Anti-estrogen kunye blocker estrogen kunye aromatase inhibitors oko ukulungisa yonke into. La machiza, nakuba kunjalo, kufuneka iimpembelelo ezilungileyo nezingalunganga kwabasetyhini kunye namadoda.

Iintlobo estrogen-blocker nokusetyenziswa kwazo

Kukho ezininzi iintlobo ezahlukeneyo estrogen-blocker. aromatase inhibitors okunene ukuvimba imveliso estrogen. modulators ukukhetha estrogen receptor, ezifana "Tamoxifen" "Clomiphene", ezenzelwe ukuba ukuvala receptors estrogen, kwaye aziphathe ngendlela eyahlukileyo kwiintlobo ezahlukeneyo ilaphu. Antiestrogens futhi ukuvimba receptor estrogen.

Antiestrogens kuthintela uguqulelo testosterone ukuba estradiol kunye hormone estrogen liyayeka ukusebenza okanye ithintelwe.

Xa unyango umhlaza, la machiza asetyenziswa ukuba isantya uphuhliso yamathumba. Kulo mzekelo, uyakhetha modulators receptor estrogen nga kuthagethwa ukuze receptors estrogen ethile. Blocker, kuquka "Clomiphene" kwakhona ngamanye amaxesha isetyenziswa kunyango nenzalo, ukuze sincede abanye abafazi abaye kunzima ngokukhulelwa. La machiza nazo ezisetyenziswa kwezinye oonoklinikhi kwi unyango abantwana lokufikisa kwalibaziseka de umdala ngokwaneleyo.

Phakathi bodybuilders wenza ukusetyenziswa estrogen-blocker ngenxa isiphumo estrogenic kwamazinga aphezulu testosterone emzimbeni. Testosterone i siphu- i estrogen, aromatase inhibitors ingasetyenziswa ukumisa ukuyilwa zihlunu engaphezulu zesininzi estrogen, ukugcina inqanaba elisezantsi emzimbeni. Esi sithethe siye sakhanga abaninzi, ingakumbi xa amachiza-estrogen zisetyenziswa ikakhulu iinjongo mhle. Kulo mzekelo, abantu usebenzisa iipilisi kunye nezongezelelo zesondlo ngaphandle kweliso zonyango.

imiphumela emibi

Kukho iziphumo ebezingalindelekanga amachiza-estrogen. Zinokubangela isiyezi, intloko ebuhlungu, ukubila, komzimba kunye nokudideka. endocrinologist kuphela isigqibo esithathwa kufanelekile ukuba isigulane ngokuxhomekeke meko, kunye umbundu owamkelekileyo yeziphumo ebezingalindelekanga. Le endocrinologist kananjalo amisele iimvavanyo zegazi qho kumanqanaba hormone xa kuhlolwa impilo jikelele isigulane ukuqinisekisa ukuba ukusetyenziswa anti-estrogen ikhuselekile kwaye iyasebenza umguli.

unyango abantu

Nge ubudala, into eyindoda amanqanaba testosterone iyehla. Noko ke, ukuba testosterone sincitshiswe ngokukhawuleza okanye kakhulu, oku kukhokelela kuphuhliso okhawulezileyo. Le meko luphawulwa nokungakwazi komzimba lokuvelisa hormone ebalulekileyo, kunokubangela ezahlukahlukeneyo iimpawu, kuquka:

• ukulahleka yobuntu;
• ukuncitshiswa imveliso kunye nomgangatho sperm;
• kwekhono erectile;
• ukudinwa.

Ukuba sithethe estrogen, abantu into yokuqala bacinga ukuba le yincindi obhinqileyo, kodwa ubukho balo kuqinisekisa ukuba umzimba inkunzi lisebenza kakuhle. Kukho iindidi ezintathu estrogen: estriol, estrone kunye estradiol. Estradiol - likwimo ephambili estrogen esebenzayo ebantwini. Zidlala indima ebalulekileyo ekugcineni umsebenzi amalungu inkunzi isicwili sobuchopho. iziyobisi Antiestrogen ikwavumela yobudoda ukuphuhlisa kakuhle.

kungalingani hormone - ukunyusa umgangatho estrogen nokwehla testosterone - kudala iingxaki. estrogen eninzi kakhulu emzimbeni iinkunzi kunokukhokelela:

• gynecomastia (uphuhliso ngokugqithisileyo inwebu webele);
• iingxaki sentliziyo;
• nengozi yokuba ngesibetho;
• umzimba;
• Iingxaki kunye endlaleni.

Unako ukuthatha amanyathelo ezininzi ukubuyisela ukulingana kwizinga estrogen. Umzekelo, ukuba estrogen yakho agqithisileyo esidityaniswe amaqondo aphantsi testosterone, oko kunokuba luncedo njenge therapy testosterone replacement estrogen blocker.

Pharmaceutical estrogen-blocker

Ezinye iimveliso zamayeza unako ukuvelisa isiphumo estrogen-ethintela ebantwini. Njengomgaqo, amaxesha amaninzi ke zenzelwe ukuba zisetyenziswe ngabafazi, kodwa ngokuya ethandwa phakathi kwabantu, ingakumbi abo banqwenela ukuba abantwana. yongezelela testosterone kunokukhokelela ukungachumi. Kodwa estrogen blocker ezifana "Clomid" unako ukubuyisela ukulingana kwamadlala ngaphandle kokuqhatha wenzala.

amachiza amaninzi zaziwa ngokuba modulators estrogen receptor ukukhetha, ngokokuqhelekileyo nawokwazisa machiza ukuba unyango umhlaza webele. Kodwa nazo zingasetyenziswa ukuvimba estrogen emadodeni. La machiza asetyenziswa ezahlukeneyo iimeko ezinxulumene testosterone phantsi, kuquka:

• nenzalo;
• eliphantsi yenzala;
• gynecomastia;
• kwamathambo.

La machiza kufuneka zisetyenziswe emane, kuxhomekeka isigulane. Ukusebenzisa enjalo amachiza-estrogen. Ngelo kwikhemesti ungathenga:

• "Tamoxifen".
• 'Arimidex'.
• "Letrozole."
• "Raloxifene".

Effects on ithambo

Ngokutsho oonoklinikhi, ukuba sesichengeni ixesha elide kumachiza estrogen kunokubangela umhlaza endometrial kwabasetyhini. "Raloxifene" - ukuba uyakhetha estrogen receptor modulator - obunokuthintela umhlaza, emane iibhloko ukufunxeka estrogen. Eli chiza, Noko ke, inawo amandla ziyibuyisela imiphumo emihle estrogen phezu kwamathambo. Ichiza elitsha - "lasofoxifene" - ukuze silungise le ngxaki. Oku kuthintela ukulahleka kwamathambo amabhinqa postmenopausal kwaye kucutha brittleness yethishyu ithambo. Ukusetyenziswa kweli chiza sikhuselekile ngokubanzi, kodwa ukwandisa egazi.

imithi

Estrogen blocker "Tamoxifen" lunokunceda ukuthintela isifo somhlaza. izigulane ezinomhlaza basoloko behlelwa kukudakumba, kwaye eli qela iziyobisi inokusebenza kakubi kunye amayeza, yokunciphisa. Ukuba isicelo "Paroxetine", ngenxa yokuba abafazi ukuthatha "Tamoxifen" yaye "Paroxetine", umngcipheko ngaphantsi wokufa ngaphezu abasetyhini abathabatha "Tamoxifen" kunye nayiphi na enye yeQela. Oku kubangelwa kukuba "Paroxetine" yenza zikhethwe.

arhente Antiestrogen kunye neziyobisi

Le lezibhengezo zonke ezi mali zibonisa ukuba ichiza ngalinye isetyenziswa ngabanye indlela kwimeko ethile.

"Clomid" okanye "clomiphene citrate" ngomnye amachiza original esetyenziswa ukunyanga gynecomastia, kuba uphakamisa inqanaba umzimba ngayo testosterone zendalo. Kukho ezinye iziphumo ebezingalindelekanga ekusetyenzisweni ixesha elide, ezifana iingxaki umbono. Kukho izinto ngempumelelo ngaphezulu kwimarike, ezenza izinto ngendlela efanayo, kodwa "Clomid" isekhona ukuxutywa olusebenzayo bangasukela nayiphi na imbaleki.

Le asinto steroid steroid, ichiza ngokuqhelekileyo emiselweyo nje ngoncedo amabhinqa nenzalo, kuba unendlela ngokukhawuleza ukukhuthaza ovulation, nto leyo kufikelelwe ngokubhloka / ukunciphisa ifuthe estrogen emzimbeni. Ukuze ube ngakumbi ngqo, "Clomid" - iimpawu chemical zokwenziwa estrogen agonist / yokuqala. Zomzimba ezithile ekujoliswe kuyo zinokuyithintela ukukwazi estrogen ukubophelela ukuya receptor ahambelanayo. ukusetyenziswa kwayo yinto ukulwa ngengxelo elibi estrogen kwinkqubo ngxenye-yebhinqa-ovarian, ezinabisa ngokukhululwa LH kunye FSH. Konke oku kukhokelela ovulation.

Ngeenjongo yezemidlalo "clomiphene citrate" besifazane akukho isiphumo. Ngabantu, Noko ke, kukho ukwanda kwemveliso ye FSH kunye (ikakhulu) luteinizing hormone elikhuthaza testosterone yendalo. Le effect kuyingenelo ngakumbi ukuya yembaleki ekupheleni komjikelo steroid xa amanqanaba testosterone iqala udangele. Ngaphandle testosterone (okanye ezinye androgens), "cortisol" kulawula kwaye ichaphazela protein amagama in kwezihlunu. Kodwa ngokukhawuleza "utya" uninzi esihlunwini ndilufumeneyo emva ukurhoxiswa. Clomid ingadlala indima ebalulekileyo ukuvimbela ukusilela ukufezekisa iziphumo zemidlalo. Kuba namankazana, inzuzo amanyathelo Clomid - Ukwazi ukulawula kwinqanaba estrogen iqala. Oku kuya kwandisa ilahleko amafutha kunye izihlunu, ingakumbi kwiindawo ezifana kwamathanga kunye ngeempundu. "Clomiphene citrate" Noko ke, ngokufuthi ivelisa iziphumo ebezingalindelekanga kwabasetyhini, kodwa, nangona kunjalo, imfuno phakathi kweli qela labadlali.

"Tamoxifen" ethintela receptors estrogen eziseleni umhlaza webele. Oku kunqanda lo estrogen ukuba yokuxoxisana nabo kwaye uthintele ukukhula nokwahlukana kweeseli. Ngoxa "Tamoxifen" usebenza njenge antiestrogen kwi iiseli mammary ndlala, esisebenza ngayo njengoko estrogen kwezinye iithishu: bone kunye esibelekweni.

Abasetyhini kunye nencum "Tamoxifen" somhlaza oxhomekeke invasive ingasetyenziswa iminyaka 5-10 emva kotyando, ukunciphisa amathuba yokusasaza Ukudlulela. Oku kunciphisa ingozi yokuba nomhlaza kwezinye ibele. Kuba kumabakala okuqala eli ukulungiselela isetyenziswa ikakhulu ngenxa kwizigulane musa ukuya exesheni. Aromatase inhibitor unyango ikhethwayo kwabasetyhini ngxaki.

"Tamoxifen" naye angayeka ukukhula okanye nciphisa nangezilonda kwizigulane kunye izigulane ezinomhlaza kuwenza. Kananjalo zingasetyenziswa ukunciphisa ingozi yokuba iinkqubo onkologicheskihz ibele.

Eli chiza sithathwa ngomlomo, ngokuqhelekileyo ngokohlobo amacwecwe.

iziphumo ezibi zamachiza anti-estrogen ziquka ukudinwa, komzimba, kome lobufazi okanye umvumbi kunye zokulwa nale ngxaki.

Amanye amabhinqa kunye metastases kwi esiqwini amathambo zingenzeka intlungu ukudumba kwi izihlunu namathambo. Oku kudla buphele, kodwa kwiimeko ezithile ezinqabileyo, abasetyhini banakho kananjalo ziqulunqe amazinga aphezulu icalcium egazini, nto leyo prokontroliruesh. Ukuba oku kuyenzeka, ngoko unyango na ukurhoxiswa kwexesha elithile.

Iziphumo ebezingalindelekanga ezinqabileyo, kodwa ngaphezulu kakhulu nazo kuyenzeka. La machiza kunokwandisa umngcipheko wokuhlaselwa ngumhlaza myometrium kwabasetyhini kunye exesheni. ekunqandeni yegazi eyonyukileyo kunokwenzeka elinye nemiphumela emibi kakhulu. Deep vein thrombosis kwenzeka, kodwa ngamanye amaxesha isiqwenga ihlwili legazi bangazilahla yaye ekugqibeleni ukuvala kwemithambo emiphungeni (Embolism pulmonary).

Ayifane "Tamoxifen" yaba unobangela kwamalungu omzimba nokuhlaselwa zentliziyo abafazi postmenopausal.

Kuxhomekeke kwimo ngxaki yamabhinqa "Tamoxifen" kunokuba nemiphumo ezahlukeneyo ithambo. Xa abafazi premenopausal, "Tamoxifen" kunokubangela ukuxozwa emathanjeni, kodwa abafazi post-ngxaki kwandisa kwinqanaba ikhalsiyam, kuyimfuneko ukuba amandla ithambo.

Inzuzo eli chiza luyazedlula imingcipheko phantse kubo bonke abasetyhini ukuba unomhlaza webele wesibeleko esigqibeleleyo hormone-oxhomekeke.

Ngokufanayo, ichiza "Toremifene", nto leyo ivunyiwe ukwenzela unyango umhlaza webele kuwenza. Noko ke, eli yeza kuya kusebenza xa esetyenziswa yi "Tamoxifen", kodwa ngaphandle isiphumo.

"Fulvestrant" sisiyobisi oluthintela estrogen receptor kuqala, uze emva koko kwakhona kususa receptor amandla ayikokubambana ngendlela. Kusebenza an anti-estrogen wonke umzimba.

"Fulvestrant" lisetyenziswa ukunyanga ukubaleka umhlaza webele kuwenza, yaye ezininzi zisetyenziswa emva namanye amachiza hormone ( "Tamoxifen" kwaye aromatase inhibitors) apho iyeke ukusebenza.

Iziphumo ebezingalindelekanga Common ingaquka komzimba, ukubila ebusuku, isicaphucaphu ngobulali nokudinwa. Enyanisweni, ukuba buthathaka amathambo (osteoporosis), ukuba kuthathwe ixesha elide.

Eli chiza liye iphumelele ingqalelo ukusetyenziswa amabhinqa postmenopausal abangenazo ukuphendula "Tamoxifen" okanye "Toremifene." Ngamanye amaxesha isetyenziselwa injongo eyenzelwe yona kwabasetyhini premenopausal, ngokufuthi ezidityaniswe kunye luteinizing ihomoni-ukukhupha agonist ukucima zamaqanda.

"Raloxifene" esetyenziswa ngabasetyhini lokhuseleko kunye nonyango lwe kwamathambo okanye kwamathambo emva ukuya exesheni. Kuyanceda ukuba ukugcina namathambo omeleleyo, ukunciphisa ubungozi waphuka.

"Raloxifene" Kwakhona na ukuthintela ukwenzeka somhlaza webele ezonakalisayo emva ukuya exesheni. Yena hormone estrogen, kodwa wenza ngathi estrogen kwezinye iindawo zomzimba, ezifana ethanjeni. Kwezinye iindawo zomzimba (webele wesibeleko), "Raloxifene" lisebenza nje blocker estrogen. Yena akumkhululi iintlobo ngxaki syndrome. Raloxifene inxulumene udidi iziyobisi eyaziwa ngokuba estrogen uyakhetha receptor modulators-SERMs (estrogenic kunye neziyobisi antiestrogenic).

amachiza Anti-estrogen and Sports

Amanye amachiza ezisetyenziswa kakhulu bodybuilders ukwakha izihlunu.

"Cyclofenil" - into neanabolichesky steroid / androgenic. Isebenza njengento anti-estrogen kunye testosterone njengoko ivuselela. "Cyclofenil" i estrogen buthathaka kakhulu kwaye nowobulali, kodwa ubophelela receptors estrogen kwaye uthintele nomphetho receptors estrogen zendalo. Enyanisweni, isebenza kakuhle kangangokuba abanye abadlali uthathe iziyobisi ngexesha unyango steroid ukwenzela ukugcina amaqondo aphantsi estrogen. Isiphumo - ukunciphisa ubungakanani ulwelo emzimbeni, nto leyo wadalwa steroids kunye nokuncipha gynecomastia. Womdlali unalo aqinise onzima, esebenzisa iziyobisi ezinjalo, nto leyo ngokumandla kuthathwe ngexesha ukulungiselela ukhuphiswano. Bodybuilders, kunjalo, sebenzisa ngaphantsi ngokufuthi kuba Ndikhetha 'Nolvadex' ifikeleleke ngakumbi yaye 'Proviron. "

Kanye "Clomid", "Cyclofenil" into nokungaphumeleli kwabasetyhini, njengoko iba nefuthe elihle kuphela ekuvelisweni hormone ngabantu. Ukuphakamisa izinga testosterone okubangelwe yile chiza akwanelanga ukuthetha uphuculo ezinkulu, kodwa iza kubonelela amandla inzuzo, nkqu ukunyuka encinane ubunzima bomzimba, ukwanda kakhulu amandla kunye nokwanda ekuzalweni okutsha kunokwenzeka. Ezi ziphumo ibonakala ngakumbi leembaleki oluphambili abaye babe namava encinane okanye akukho kunye steroids. Sebenzisa iziphumo sibonakale kuphela emva kweveki.

Kwezinye iimeko, iimbaleki babukela mlilo ezifana amaqhakuva, drive sex eyonyukileyo kunye ukufikelwa. Ezi mpawu ubungqina ingakumbi kubonisa ukuba umchiza liyi- olusebenzayo. Emva ukupheliswa ezinye ingxelo mood odandathekileyo ukuhla okuncinane ngamandla ngokwasemzimbeni. Abo uthathe iziyobisi njengento anti-estrogen ngexesha unyango steroid, uyakwazi ukubona isiphumo esahlukileyo xa isiphumo kwiarhente wayeka.

"Proviron" yenye yezona steroid ezindala steroid androgenic ezivenkileni. Ngokusesikweni eyaziwa ngokuba yi "Mesterolone", oko kuhlala omnye kakhulu engafunwanga phakathi kubasebenzisi steroid steroid.

Ngokuqeshwa olusebenzayo Proviron inemisebenzi emine engundoqo, nto leyo kakhulu ukumisela indlela emayihambe ngayo. Kuqala kwinto zonke, nguye ngomnye steroid zinamandla steroid, kuba oko konyusa ubungakanani elijikeleza testosterone simahla, nto leyo ebaluleke kakhulu steroid iinkqubo bodybuilders. Indlela elula ukujonga ukuba: Ukuba ngaba uthatha steroid, ubunzima kwezihlunu liyenyuka.

"Proviron®" unekhono ukuba basebenzisane aromatase enzyme, nenoxanduva zokutshintshwa testosterone ukuya estrogen. Ngokuzibophelela kwi aromatase, "Proviron®" ndingekawuboni zinqanda umsebenzi wayo, ngaloo ndlela ukhuselo kwiimpembelelo ebuhlungu estrogen.

On "Mesterolone" une kaBorrow womelele receptor androgen. Le steroid steroid loo nto ukucinezela gonadotropins kuyafana nezinye steroid. Oku kwenza kube lula ukwandisa imveliso madlozi kunye njengoko androgens ayimfuneko nokukhuthaza spermatogenesis. Oku akunyusi nje kuphela inani amadlozi, kodwa kuphucula ubulunga bayo.

Effects Side "Proviron" musa ziquka gynecomastia okanye fluid kwemfuneko. Oku kuya kuthi kananjalo kakhulu ukunciphisa ingozi yokuba uxinzelelo lwegazi oluphezulu ezinxulumene ne steroid. Enyanisweni, "Proviron" ngandlela anti-estrogenic ngokunqumamisa ukuguquka kwazo testosterone ukuya estrogen, okanye ubuncinane isantya le nkqubo.

Amachiza zikhankanywe ngasentla musa yethise nobuninzi be-estrogen kodwa kuchaphazela yokucolwa ngokubanzi.

Iqela amachiza antiestrogenic zikwaquka agonists ukukhupha izinto iihomoni gonadotropic ( "Buserelin" kunye analogs ayo), megestrol acetate ( "Megeys") "Parlodel" yaye "Dostinex" zisetyenziswa iziyobisi, asimise prolactin secretion. ukusetyenziswa yazo ku ukunyanga non-enengqondo.

Unyango umhlaza

Ukongeza "Tamoxifen" Le blocker estrogen receptor elandelayo.

amachiza amathathu ukuba bayeke imveliso estrogen amabhinqa postmenopausal, ziye zavunywa ukunyanga zombini kwangethuba kwaye phambili umhlaza webele: "Letrozole" ( "Femara"), "Anastrozole" ( 'Arimidex') kunye 'Exemestane "(" AROMASIN ") .

Indlela yesenzo iziyobisi anti-estrogen kweli qela - ikwaxina ze enzyme (aromatase) e izihlunu adipose, elinoxanduva imali encinci estrogen amabhinqa post-ngxaki. Abayi azichatshazelwa amaqanda, ngoko kuphela olusebenzayo abo nabafazi amaqanda azisebenzi, mhlawumbi ngenxa exesheni okanye ngenxa impembelelo luteinizing hormone analog. La machiza zithathelwa imihla ifomu ipilisi. Zisebenza kakuhle ngokulinganayo unyango kweenkqubo oncological emabeleni wesinye.

Ngamanye amaxesha unyango umhlaza webele kufuna ovarian zonyango. Oku kungenziwa namachiza analogue of luteinizing hormone-ukukhupha hormone (LHRH), umzekelo, "Goserelin" ( "Zoladex") okanye "leuprolide" ( "Lyupron"). La machiza asithe uphawu leyo uthumela ukuba umzimba zamaqanda ukuvelisa estrogen kubo. Zinokusetyenziswa wedwa okanye "tamoxifen", aromatase inhibitors, "Fulvestrant" zazo kunyango kwamadlala kwabasetyhini premenopausal.