Preparart "Lucentis": Iimpendulo zezigulane amagqirha, imiyalelo zokusetyenziswa

Kweli nqaku siza kuthetha mveliso amayeza "Lucentis". Imiyalelo, ukubuyekeza, idosi - konke oku yaye kokukhona uya lingcwaliswe.

"Lucentis" elisetyenziswe zamehlo kuba unyango lwe yamehlo macular ezinxulumene-ubudala (neovascular). Kwakhona isetyenziselwa seswekile macular nokudumba ukubuyisela umbono. Ichiza ilawulwa ngenaliti emzimbeni vitreous iso.

Isakhiwo kunye Nokuhlanganiselwa

It is a ukulungiselela isisombululo ngaphaya okanye opalescent kancinane yolawulo "Lucentis" yangaphakathi (ratings isigulane ukuqinisekisa it).

Eyona nto iphambili ebonakalayo ichiza ranibizumab. umxholo wayo igutyana iziyobisi 1st ngu 2.3 mg. Ukongezelela, amacandelo abangabancedani zilandelayo zibandakanyiwe kwi "Lucentis":

• dihydrate α-trehalose;
• polysorbate;
• L-histidine hydrochloride monohydrate;
• amanzi.

Elinye ibhokisi ne ichiza ziquka:

• nebhotile ecacileyo, kukho umthamo we 0.23 ml, ichiza;
• yinaliti elitsha icebo;
• A ngesirinji wawuqalekisa inaliti.

Ichiza iyekelela ezikhemisti ngokumiselwa kuphela.

ubungqina

Faka inani kwezifo lwamehlo "Lucentis". Baqinisekiswa kakhulu edidayo malunga ukusebenza kwayo - ukuba umntu ichiza kunceda, ngoxa abanye ngenkankulu uyakubona ukusebenza kwayo. Noko ke, "Lucentis" ezimiselweyo zigulo zilandelayo:

• uhlobo emanzi (neovascular) of degeniratsii macular ezinxulumene-ubudala;
• ukungaboni ngenxa kuphuhliso seswekile macular nokudumba - ukusetyenziswa ngexesha elinye-okanye idityaniswe laser coagulation ;
• kwamehlo ngenxa nokudumba macular, nto leyo ibangwa semehlo vein occlusion;
• kwamehlo ngenxa neovascularization choroidal okubangelwa ukubona yezifo.

Izimo

Kukho intaphane Izimo ngenxa yokuqeshwa ichiza "Lucentis". Izigulane izimvo nayo ibonisa ukuba ichiza emiselweyo ukuba wonke. Ngenxa yoko, ichiza kungavumelekanga ukuba isetyenziswe kwizigulane:

• abaphethwe zizifo ezosulelayo of ocular okanye periocular ezithandwa iinkqubo esosulelayo eyendawo;
• lowo wafunyaniswa "nangokurhala intraocular";
• nedostrigshim eyi-18 ubudala;
• ababonisa hypersensitivity na Yinxalenye beziyobisi.

Ichiza kwakhona asikwazi kwenziwa ngabo abafazi abakhulelweyo kunye phindeke.

Ichiza isetyenziswa ngobunono izigulane kwezi ndidi zilandelayo:

• Abantu hypersensitivity; ukuba kukho amathuba okuba nestroke, ichiza kuphela emva kokuba uhlolo kumagqirha risk-bazuza "Lucentis".
• Izigulana DMO ngenxa semehlo occlusion umthambo okanye CNV, nto leyo ibangwa ukubona lwezidumbu, ubukho ischemia ubuchopho okanye ngesibetho - ichiza kungadala thromboembolism.
• Abantu sele uthathe iziyobisi ukuba senze kukhulo endothelial nemithambo.

Kwezinye iimeko, unyango uphazamiseka

Kukho iimeko apho kukho imfuneko engxamisekileyo ukuba ziphazamise unyango yaye akazange azame ukuba bavuselele:

• utshintsho koxinzelelo intraocular ukuya mmHg-30 okanye ngaphezulu. Inqaku.;
• ukuncipha acuity olubonakalayo ngeencwadi-30 okanye ngaphezulu xa kuthelekiswa nomlinganiselo lokugqibela;
• iinyembezi semehlo;
• subretialnoe yokopha, echaphazela una central, okanye wambetha kwama-50% kule ndawo;
• ekuqhubeni uqhaqho intraocular.

balawule

Kuphela uhlobo lwezitofu vitreous "Lucentis" iyasetyenziswa. Baqinisekiswa zibonisa ukuba inkqubo kukodwa elula.

Okubhalwe lithetha ibhotile enye bujolise kuphela inaliti enye. Yazisa akakwazi zamehlo kuphela amava neenkqubo ezinjalo iziyobisi.

Ekubeni unyango lubandakanya izitofu ezininzi, kufuneka kukhunjulwe ukuba phakathi kwabo kufuneka babonwe lokuphumla kwinyanga ubuncinane 1. Ithamo ekucetyiswa "Lucentis" ukuba isitofu esinye - 0.5 mg. Ngexesha unyango kolawulo esisigxina phezu ndikho kufuneka zenziwe.

Xa kutyunjwa ichiza kwizigulana kweminyaka engama-65 kufuneka uhlengahlengiso idosi okhethekileyo.

"Lucentis": imiyalelo yokusebenzisa

Ukuphonononga ekulungiseleleni kunye nomsebenzi oogqirha bathi isigulana kuyimfuneko ukuba esweni amalungiselelo ukulungiselela ukuqaliswa kwenkqubo ukuze acace.

Ngoko ke, ngaphambi kokuba ukuqaliswa ngezixhobo eziyimfuneko ukuze uqinisekise ukuba isisombululo ichanekile - umbala, imvakalo, ukungabikho yodaka. Xa ukutshintsha ithowuni okanye ubukho amasuntswana ezingenakunyibilika "Lucentis" esalelweyo ukuyisebenzisa.

Intshayelelo yokulungiselela kufuneka kwenzeke phantsi kweemeko engenazintsholongwane: izandla kwipharamedikhi, kufuneka ngokufanelekileyo ngayo; zisetyenziswa iiglavu engenazintsholongwane kuphela, kufuneka ube usula engenazintsholongwane isiciko speculum kunye nezinye zonke izixhobo eziza kusetyenziswa.

Nje phambi kokuba isitofu lwenziwa kweentsholongwane inwebu yamehlo kunye nobudala. Ke ngedriphu iintlungu yaphathwa antimicrobials. Kufuneka kukhunjulwe ukuba amagosa anti-ngeentsholongwane kufuneka wabethelela ka-3 ngosuku phambi nasemva kwenkqubo iintsuku ezintathu.

Kuphela phantsi kwale mithetho inokuba unyango yimpumelelo "Lucentis". Ingxelo evela kwabo ayithimba, besithi ukuba kukho amaxesha xa ugqirha ufaka ichiza kwizigulane ezimbini yenaliti efanayo. Enjalo azamkelekanga kwaye kunokukhokelela usulelo lweNTSHOLONGWANE ezahlukeneyo kunye nezifo ezifana nogawulayo.

Drug ngokwayo ilawulwa emzimbeni vitreous ngokusikhokela incam inaliti ngasembindini lweliso lakho. izitofu elandelayo kufuneka yenziwe kwenye nesiqingatha sclera, apho ayichaphazeleki inaliti yokuqala.

Ekubeni iyure emva kokuba inkqubo, uxinzelelo intraocular nivuke, kuyimfuneko ukulawula nokujonga perfusion ye-luvo optic. Kwiimeko kokokunyanzelwa kufuneka ukuba ukunika unyango ukuba azole ukuhlisa uxinzelelo.

Inkqubo mntu uvumelekileyo ukuba angene ichiza kuphela iliso elinye.

libanda

libanda ngengozi ziye zaphawulwa ngexesha yolingo lwezonyango. Ezi mpawu zixhaphakileyo yale zezi:

• ubuhlungu eyomeleleyo elibukhali emehlweni;
• noxinzelelo intraocular.

Ukuba uqaphela iimpawu ezinjalo isigulane kufuneka abe phantsi kweliso ugqirha uye unyango kuyimfuneko.

Intsebenziswano kunye namanye amachiza

Akwaziwa ngayo kunye namanye amachiza imithi "Lucentis". Izimvo ezigulane (uninzi lwabo) kukhokelela kwisigqibo sokuba oogqirha musa ukumisela i "Lucentis" nayiphi na into namanye amachiza ngaphandle iintlungu kunye anti-infective.

Oku kungenxa yokuba uphando kwi impefumlelwano 'Lucentis "kunye namanye amachiza azikhange kuqhutywa. Ngoko ke, amayeza kufuneka lusetyenziswe kunye nezinye izisombululo okanye iziyobisi.

Ukukhulelwa ne zisanyisa

Ngaba contraindicated ngayo abasetyhini abakhulelweyo kunye phindeke ahlabe 'Lucentis "(iimpendulo kwakhona ukuqinisekisa oku). Oku kungenxa yokuba ichiza kucingelwa ukuba yenye yezona iziyobisi yaManzi naMahlathi kunye embryotoxic, oko kukuthi, yenza eli thole kakuhle.

Kuba namakhosikazi aselekhulile yokuzala, lekhefu phakathi ekupheleni unyango kunye ukukhulelwa kufuneka ungabi ngaphantsi kweenyanga ezi-3 - ngelo xesha ranibizumab ukuba ngokupheleleyo umzimba. De kube lelo xesha, kufuneka usebenzise zokucwangcisa ethembekileyo.

imiphumela emibi

Kwaye kungabangela iimpembelelo ezingathandekiyo wadutyulwa iliso ( "Lucentis"). Izimvo lwezigulana noku kakhulu ezakhayo - iziphumo ebezingalindelekanga ezinqabileyo kakhulu. Noko ke, amaphononongo lwezonyango nyaka-emibini sichonge ziphumo zilandelayo kakhulu kokungafunekiyo lezempilo emva kokuba isitofu:

• endophthalmitis;
• lamabutho semehlo ;
• cataract;
• noxinzelelo intraocular;
• nokudumba intraocular.

Ukongeza, iziphumo eziqwalaselwa akanangozi usebenzise "Lucentis" ezinxulumene amalungu kwamehlo:

• ukudumba komzimba vitreous kunye intraocular;
• lamabutho vitreous;
• ukungaboni;
• yokopha semehlo;
• intlungu emehlweni;
• yokopha conjunctival;
• blepharitis;
• ukuluma amehlo;
• amehlo alilayo;
• syndrome amehlo owomileyo;
• iritis;
• uveitis;
• yehle acuity ebonwayo;
• Spike iris;
• iinkqubo sisiba mandundu kwiretina;
• anozizi esweni.

Kananjalo wadibana iziphumo ebezingalindelekanga kulandelayo:

• nasopharyngitis;
• influenza;
• ukukhathazeka;
• igazi;
• intloko;
• ngesibetho;
• ukukhohlela;
• isicaphucaphu;
• ukurhawuzelelwa krwada;
• arthralgia.

Nangona kunjalo, ezi ziphumo bezingalindelekanga ngaphantsi kwe-2% amatyala lithetha "Lucentis" ukusetyenziswa. Ncomo, ngokukodwa, zibonisa kwisehlo rhoqo noko ububomvu kunye neentlungu. Nangona kunjalo, ezi mpawu shwaka kunokuba ngokukhawuleza.

iimeko yokugcina

"Lucentis" kufuneka zigcinwe ngama-2 ukuya ku-8 Celsius, kodwa noko kunjalo musa ngumkhenkce. Kuthethwa kuyimfuneko ukugcina kwindawo emnyama neyomileyo apho abantwana abakwazi ukufikelela. Ubomi lokugcinwa kwezinto ichiza iminyaka emi-3 ukususela kumhla wokwenziwa. Musa ukusebenzisa aphelelwe "Lucentis".

oyi

Xa usebenzisa 'Lucentis "bangafumana ukuphazamiseka zokubonwayo echaphazela kakubi ukukwazi isigulane ukuba basebenze iindlela ezahlukeneyo ulawula isithuthi. Ngoko ke, ukuba ezi mpawu zisekuhleni kanye, musa ukufumana emva ivili le imoto okanye khohlisa indlela kude kube lelo xesha zonke ukuphazamiseka ezibonwayo shwaka.

Kwakhona kucetyiswa ukuba aqhube isithuthi ngoko nangoko emva kokuba isitofu, nokuba uvakalelwa nto ekuqaleni abazange uqaphele. iziphumo ezingalindelekanga ukuze kwenzeka kamva, umzekelo emva kokuphela iintlungu.

'Lucentis': Ukubuyekezwa oogqirha

'Lucentis' kudla kucetyiswa kwaye kumiselwe ngoogqirha kuba kucingwa ukuba ichiza kakuhle kakhulu. Kwelinye icala, akusoloko ungamelana isigulane ukuba ahlawule imali efunekayo ye-ziphene: "Lucentis" - isixhobo kunokuba imali eninzi. Kule meko, oogqirha ukucebisa endaweni kuso umfuziselo enganeno - "Avastin". Nangona kunjalo, le yokugqibela okwangoku iphandwayo ngomlinganiselo ofanelekileyo, ngoko ke isindululo sokuqala oogqirha yi "Lucentis" evunyiweyo. Ophthalmologists kudala wayewazi esi sixhobo, uyazi yintoni imiphumo kulindeleka kwaye ukuqaphela ukusebenza kwayo.

baqinisekiswa

Ngoku makhe sithethe ngezinto izigulane ngokwabo ucinga ngale mveliso amayeza "Lucentis". Ukuphonononga lubonisa ukuba ichiza ayisoloko zibe nezo ziphumo zinqwenelekayo. Noko ke, uninzi lwezigulane abanikwe, uthi ukuba umbono kuye kwaphucuka kakhulu okanye wayeka ukuba ukwehla. Ziphawuleka ezo mpembelelo lokugcinwa ezifana intlungu kukuvela zizifo, kodwa kulula ukumelana antibiotics. Ukongeza, uninzi lwezigulane Siqinisekile ukuba ezi iziphumo ezingafunekiyo zibangelwa.

Noko ke, kukho iimeko xa ichiza kwaba angasebenzi. Into esiza 'Lucentis' kungekhona 100% yamatyala, bathi, kunye noogqirha ngokwabo. Nangona engxakini kakhulu izigulane bakholelwa ukuba - iindleko mali. Asinguye wonke ubani onokukwazi ukuhlawula ikhosi epheleleyo lwezitofu eziliqela.

Phakathi izinto ezibalulekileyo, ukongeza ukusebenza, isicelo elingenabuhlungu ebizwa ngokuba "Lucentis" (ncomo kulo mba uyavuma). Indlala kuphela gqitha phambi ulawulo nasemva. Noko ke, ukuba kakhulu ukumelana, kwaye bazingxwelerha ngokwakhe abuzwe. Emva eyeka zomzimba, kukho iintlungu ezincinane.

Noko ke, "Lucentis" watsho isixhobo entle olusebenzayo emva kokuba isicelo apho izigulane amava ngcono umbono.