Imiyalelo ukusetyenziswa, ingxelo kunye analog "Ketanova"

Kutheni amisele analog "Ketanova" Wathi ichiza ngokwawo? Oku uya ukufunda izinto wenqaku. Kwakhona ukwethula kini ukuba imiyalelo ngokusebenzisa iyeza, ukunika ulwazi kwifom release, ukusabela oqatha, ukwakheka, Izimo, iindleko njalo njalo.

Ubume, ukupakishwa, ifomu ukukhululwa

Togu "Ketanova" kwaye zimelwe yi sixhobo ngokwalo babe ifomu eyahlukileyo ngokupheleleyo woyekelelo. Isabelo ixhomekeke kuhlobo intlungu, indawo ekuyo yaye kwimeko yomguli.

Okwangoku, iziyobisi "Ketanov" ifumaneka ngeendlela ezimbini ezahlukeneyo. Thina uqwalasela ngamnye kule zolwimi ngokunzulu.

• amacwecwe bhanya-camera. Ilungu elikhutheleyo ichiza ketorolac tromethamine. Njengoko yezigqeba abangabancedani, ngoko ke ziquka umbona starch, nemagnesium stearate, microcrystalline neselulosi kunye colloidal lesilicon dioxide. Ukubunjwa ukutyabeka bhanya iquka amacwecwe hydroxypropylmethylcellulose, amanzi okuhlamba, polyethylene ethers, titanium dioxide kunye talc nyulu. Kufuneka kuqatshelwe ukuba loo analog "Ketanova" njengoko "Ketorolac", iqulethe into efanayo esebenzayo. ukulungiselela kujongwa ithunyelwa namadyungudyungu aluminiyam, ezithi zibekwe imfumba kwikhadibhodi. Omnye phakheji inokuba ukusuka macwecwe ezilishumi nekhulu.

• Inaliti "Ketanov". Lwezitofu, analogue zazo ziboniswa ngezantsi, nazo ziqulathe oku Isithako esisebenzayo njengoko ketorolac tromethamine. Ukongeza, isicombululo iquka kumafa layo kunye namasebe abangabancedani ngohlobo sodium chloride, amanzi inaliti, disodium edetate, ethanol kunye sodium hayidroksayidi. Amayeza kuthengiswa nengqayi ye milliliter omnye. Ibhokisi inokuba ezintlanu okanye ezilishumi yentsha.

Iimpawu pharmacodynamic ye iintlungu

Ziziphi iimpawu pharmacodynamic zigqalwa neziyobisi elilingana neli? "Ketanov" (tablets nezitofu) kunempembelelo iintlungu libizwe. Eli chiza eliphakathi iipropati antipyretic kwaye anti-ukudumba.

Ngokutsho iingcali, umgaqo amanyathelo beziyobisi ezinxulumene inhibition umsebenzi enzyme Cox-2 kunye Cox-1 (non-uyakhetha). Le nkqubo yenzeka kwizihlunu zomzimba. kuzichanaba ebangela inhibition ka PG biosynthesis, okt modulators thermoregulation, ubuzaza iintlungu kunye nokudumba.

Amacwecwe Application "Ketanov" okanye ulawulo intramuscular yezisombululo ikhuthaza ukuyilwa a racemic umxube [-] S- kwaye [+] R-enantiomers. Ke kaloku, isiphumo iintlungu beziyobisi kungenxa kuphela [-] S-imilo.

Kufuneka ube ngokukodwa kuqatshelwe ukuba medicament esebenzayo akuthethi zisidimaze yokuphefumla, alunasiphumo kwi ii-opioid, ayenzi ilifa ukusebenza anxiolytic kwaye umthomalalisi kwaye akubangeli ukuxhomekeka.

Into ekufuneka uyazi phambi kokuthatha le mveliso okanye ibakala elilingana neli? "Ketanov" (iipilisi kunye iinaliti) emandleni yegalelo iintlungu ufana kuphela ukuba icaffeine. Ngokutsho kweengcali, oku kuthetha mkhulu kakhulu onke amanye amachiza non-steroidal.

Emva ukusebenza nolawulo iintlungu ngomlomo okanye intramuscular uyaqapheleka iyure enesiqingatha, ngokulandelelana kwazo. Isiphumo esiphezulu beziyobisi iyazalisekiswa ngokusebenzisa imizuzu 60-120.

iipropati pharmacokinetic

Ichiza yokuqala, kwakunye nawuphi na analogu "Ketanova" emva kokungenisa wendele kunokuba kakuhle kwisiqwenga zesisu. Ukufumaneka liphezulu kweziyobisi egazini kuphunyelelwa emva malunga yimizuzu engamashumi amane emva kokungenisa ezile ukutya iipilisi (10 mg). Kufuneka kuqatshelwe ukuba ukuselwa ukutya olunamafutha kunye junk unga nciphisa ngokubaluleka xi iphezulu ichiza egazini kwaye ugcine impumelelo yakhe kwimizuzu zaba ngamashumi omathandathu.

Malunga 99 ekhulwini mali lubotshelelwe iiproteni plasma. Xa inani izinto hypoalbuminemia simahla kwi kwandisa egazini. Ngokumalunga bioavailability beziyobisi, kuba malunga 80-100%.

Ukuba ulawulo intramuscular leyo ngokukhawuleza nangokupheleleyo bangene ichiza yegazi "Ketanov". Analogs (Ukraine iye ekuveliseni kuphela "Ketorolac") njengoko ezabalazela kakuhle.

Emva Inaliti intramuscular 30 mg beziyobisi siphezulu micrograms yayo xi 1,75-3,2 / ml kwaye usebenzisa 60 mg - 3,25-5,75 g / ml. Le xi ubuninzi kweziyobisi egazini uyaqapheleka imizuzu eli-15-20 kunye 35-65, ngokulandelelana kwazo.

Nokuba ichiza lingena singene ubisi lwebele? Yaye kuziindleko, kwaye cheap analogue "Ketanova", yaye ingqalelo ichiza ngokulula ukungena kwi ubisi lwebele. Oku kwenzeka ngokukhawuleza emva kwedosi yokuqala medicament xa isixa milligrams-10. Ukufumaneka liphezulu ichiza milk izilinganiso kuphunyelelwa emva malunga 120 imizuzu kwaye 7.3 ng / l.

Malunga ne-50% ye idosi elawulwa beziyobisi umzimba esibindini. Ngenxa yoko, metabolites abapholileyo kwakheka. Chief phakathi kwazo gidroksiketorolak zezithili kunye glucuronides. Bona ngokubanzi izintso (malunga nama-91%) kunye emathunjini (6%).

Isiqingatha wobomi beziyobisi izigulane kumsebenzi oluqhelekileyo sezintso imalunga 5.4 iiyure. Olu ncedo luqhutywa ngonyuka anda abadala kunye ucutho abaselula.

isibindi alunasiphumo kwi besiqingatha ubomi ichiza. Kufuneka kuqatshelwe ukuba ichiza ayi veli inkqubo dialysis.

Ubungqina obubonakalayo buxela

Yintoni ukuthini iziyobisi "Ketanov"? Analogue kweziyobisi kuyimfuneko kakhulu isiqabu elifutshane elide ngomvandedwa imvelaphi ezahlukeneyo.

Ngoko ke, lo medicament ingqalelo ezimiselweyo:

• ubuhlungu postoperative (kubandakanywa emva kotyando amathambo, izifo kunye esiswini);
• lizinyo (kubandakanywa emva kotyando kwi wamazinyo);
• syndromes ubuhlungu emva kokufumana ngokwaphulwa, dislocation, kunye nomenzakalo kwizihlunu ezithambileyo;
• ubuhlungu bebelekile;
• syndromes ubuhlungu esivulekayo osteoarthritis;
• syndromes ntlungu ezibangela umhlaza;
• sciatica.

Bambalwa abantu bazi, kodwa ukusetyenziswa amacwecwe "Ketanov" nesisombululo injectable ngeke babonakale syndromes iintlungu ezingapheliyo. amachiza Ezo kuyimfuneko kuphela lokuphelisa kabi zexesha elifutshane. Ukuthatha ichiza kwithuba elide akuvumelekanga.

Izimo

Njengoko kulungiselelwa amanye amayeza ezingezo-steroidal "Ketanov" lisetyenziswa iintlungu iye Izimo ezininzi ezahlukeneyo. Kungenxa yoko le nto phambi kokuba usebenzise yona kufuneka udibane nogqirha wakho uze ufunde imiyalelo. Lukhangela Izimo zilandelayo:

• izilonda ilunga kunye sisilonda le iphecana zesisu, ingakumbi kwisigaba etsolo, hypocoagulation (kuquka kubazali) kwaye isilonda Peptic;
• ubuntununtunu Ukunyuka ukuya ketorolac nomonde kunye nezinye NSAIDs, bronchospasm, emzimbeni, angioedema, aspirin isifuba, hypovolemia (kungakhathaliseki unobangela ivela khona);
• isibindi okanye isifo sezintso (at ukusilela), ingakumbi plasma creatinine kwi-50 mg / L;
• sophele ezikuyo (kukrokrelwa ukuba kukho), ukopha diathesis, basengozini enkulu ukuphinda okanye ukopha (kubandakanywa emva kotyando), ukusetyenziswa ehamba nezinye NSAIDs, hematopoiesis kakuhle;
• yobudala ngaphantsi kweminyaka eli-16;
• Ngexa lokukhulelwa, inkqubo ukuzala kwaye ngexesha zisanyisa;
• Unyango ndinentlungu engapheliyo syndromes isimilo;
• zomzimba phambi kutyando ngexesha kubo (ngenxa yokuba ubungozi olongeziweyo ukopha).

Asikwazi athi medicament esebenzayo imiselwe ngobunono izigulane cholecystitis, isifuba inyumoniya, ukusilela intliziyo esinganyangekiyo, ukusebenza sezintso (plasma creatinine ngaphantsi kwama-50 mg / l), lwegazi, hepatitis esebenzayo, cholestasis, nokudumba, lupus lupus, ngokunjalo kule (kweminyaka 65) abadala kunye nabo polyp kwi ingaphakathi kwi nasopharynx kunye nempumlo.

Drug "Ketanov": imiyalelo yokusebenzisa

Analogs bangenayo indlela efanayo iindlela isicelo kunye balawule. Kodwa ukuze uphephe ngaphezulu phambi kokuba ukusetyenziswa kwazo Kucetyiswa ukuba aye kwagqirha.

Njani na ndisela iipilisi "Ketanov"? Olu hlobo ichiza kuyimfuneko ukuba ukuthatha enye yomlomo (10 mg). Ukuba kuyimfuneko (umz, elinamandla iintlungu syndrome) medicament ithamo unako liphindwe. Nakuba kunjalo, kufanele kuqatshelwe ukuba idosi yemihla ngemihla ichiza kufuneka mayingagqithi 40 mg.

Xa nokudla ubude ikhosi isiyobisi iintsuku ezintlanu (hayi ngaphezulu).

Ukuba ngenxa yezizathu okanye omnye sigulane asikwazi ukuthatha ngohlobo ngomlomo beziyobisi (umz, phambi ilunga okanye amanxeba sisilonda esiswini, kwamathumbu), ngoko ukuba yabelwe isisombululo ukuba isitofu. uhlobo olunjalo iphethwe intramuscularly.

Ekuqaleni unyango ngamachiza ezisetyenziswa ubuncinane iidosi esebenzayo Kukhethwe ngokungqinelana ngobunzulu okanye amandla syndromes intlungu impendulo malunga nesigulane eso. Ukuba kuyimfuneko, isigulane emiselweyo analgesics ezongezelelweyo opioid.

A ekuqulunqeni esithathwa ndingatshatanga inaliti eyodwa intramuscular:

• abantu abangaphantsi kweminyaka engama-65 ubudala - malunga 10-30 mg (ngokuxhomekeke kubungakanani intlungu);
• abantu kwiminyaka engama-65, kwakunye izigulane umsebenzi kidney othile - 10-15 mg.

Izikali emva ngokuphindaphindiweyo ulawulo intramuscular:

• abantu 65 - malunga 10-30 mg; kwandule ke elinganayo yonke iiyure ezine ukuya ezisixhenxe;
• abantu abadala ngaphezu kweminyaka engama-65 kwaye izigulane umsebenzi kidney othile - 10-15 mg qho kwiiyure 4-7.

Idosi yemihla ngemihla ichiza xa ilawulwa intramuscularly abadala akufuneki ngaphezu 90 mg. Kwizigulana abadala kunye nabo umsebenzi kidney kakuhle kuyimfuneko kukunciphisa isixa ukuya ku-60 mg. Ubude unyango kufuneka ungabi ngaphezu kweentsuku ezintlanu.

Ngethuba lenguqu ukusuka kulawulo intramuscular beziyobisi kwi amayeza kwi idosi iyonke imihla yeefom zombini mayingabi ngaphezu 90 mg kubantu abadala kunye 60 mg izigulane abalupheleyo okanye izigulane umsebenzi kidney kakuhle.

iimpawu libanda

Kunye amathamo ephezulu medicament wathi isigulane ibonakala ukugabha, iintlungu esiswini, ukusebenza kakuhle kwezintso, lactic metabolic, isicaphucaphu, gastritis ilunga kunye isilonda Peptic.

Njengoko unyango iimeko ezinjalo usebenzisa lavage esiswini kunye nokwaziswa adsorbents ezahlukeneyo. Kwakhona unyango lingaze (okt ukuxhasa imisebenzi ebalulekileyo lomzimba).

imithi

Xa isicelo odibeneyo ichiza ethathelwa ingqalelo kunye nezinye NSAIDs, isigulane lisenokuba iziphumo ebezingalindelekanga Ukongeza, kunye anticoagulants (kuquka "lweeHedfowuni" ngeedosi ezincinane with "Pentoxifylline") - ukopha.

Ukuba ukusetyenziswa ehamba ichiza kudlala ACE inhibitors, kusenokubakho izitenxo kwi kwizintso.

Kufuneka kuqatshelwe ukuba ukusetyenziswa kweziyobisi ophantsi kohlolo, with "Probenecid" kwandisa isiqingatha-ubomi ketorolac kunye ingqalelo yayo plasma.

Ukuba olu nyango kunye lithium, kunokwenzeka ukuba ukunciphisa obucacileyo sezintso lwe Lithium nokwandisa eyavela kwi plasma, kodwa "Furosemide" - yandisa isiphumo yayo umchamo.

Ngexesha isicelo i "Ketorolac" akukho mfuneko yokuba ngokuthatha analgesics opioid.

Ixesha kwiwotshi yamanani best

"Ketanov" - oku isicwangciso esiqinileyo nesinempumelelo sokukhawulelana iziyobisi iintlungu, nto wathengisa ngayo phantse yonke drugstores. Ethetha analogs zayo, kunzima ukuba igama amayeza kakhulu ngempumelelo. Ngoko ke, ngokuba isiqabu ngokukhawuleza intlungu syndrome ngokufuthi oogqirha ukumisela ukuba izigulane zabo ichiza. Kodwa ukuba ngenxa yesizathu esithile ichiza contraindicated kuwe, sicebisa ukuba uyitshintshe ufake "Ketorolac". Kuxhomekeka ixabiso yelizwe-umenzi esi sixhobo zinokuba nomahluko. Indleko ukupakisha amacwecwe Russian iqala engange-20, Ukrainian - 35, kwaye Indian - 45.

Yintoni uthathwa ichiza enye indawo? Ngaba unayo nayiphi na enye analogu? "Ketanov" ngaphandle kagqirha, ungasoloko ukuthenga kwi ekhemesti. Xa kanye ngendlela efanayo unako ukuthenga imidiya efanayo njenge "Adolor", "Torolak", "iziyobisi Akyular", "Toradol", "Dolak", "Ketofril", "Dolomin", "Ketorolac tromethamine-Farmaplant", "Ketadrop "" Ketorolac tromethamine, "" Ketalgin "," Ketorolac-Eskom "," Ketokam "," Ketorolac-Verte "," Ketolak "," Ketorolac-OBL "," Ketorolac Rompharm "," Ketorol "kunye nabanye.

Yeendleko zezi machiza ngaphezulu original kunye ngezantsi. Khumbula ukuba ichiza "Ketanov" (macwecwe 10) unako kuthengelwa 50-70 engange. Kufuneka kwakhona wathi akukho kucetyiswa ukuba ngayo ingqiqo yazo.

Yeyiphi isixhobo ukuyisebenzisa ngenxa ntlungu yasekuhlaleni? Ingaba kukho uhlobo ohambelana i "Ketanov 'iziyobisi? Wamafutha (analogs of uthe arhente kwi amacwecwe ziye zanikezelwa ngasentla) ineempahla efanayo esebenzayo kunzima ukufumana. Noko ke, kusekho ichiza ezinokuthi zisetyenziswe ngokwemixholo. Le yi-2% amayeza ebizwa ngokuba "Ketorol" (eyenziwe India). Loo ndlela ifumaneka kwiityhubhu gram-30 yaye ngokukhawuleza kususa naziphi syndromes intlungu (xa isicelo ngokwemixholo).

Izimvo ntlungu

Ngoku uyazi ukuba sisiyobisi "Ketanov", kuba yona. Kufuneka kuqatshelwe ukuba phantse zonke izigulane Izimvo le medicament ezincomekayo. Abantu rhoqo usebenzisa iipilisi okanye isisombululo ukuba isitofu "Ketanov" karhulumente ukuba ichiza enjalo khipha kakhulu ngokukhawuleza nayiphi syndromes intlungu.

Njengoko kuboniswe yi yezonyango, isiphumo iintlungu ihlala iiyure 12-15 (ngamanye amaxesha elide). Emva kweli xesha, iipilisi kufuneka uphindaphindwe (ukuba ntlungu ongenakuwelwa).

Nangona kunjalo, akunakwenzeka ukuba ukukhankanya into yokuba eli chiza, njengezinye NSAIDs, kukho ezininzi yeziphumo ebezingalindelekanga. Ngokutsho iimpendulo lezigulane, maxa wambi eli iyeza kubangela ubucaphucaphu neentlungu esiswini. Kulo mzekelo, iingcali Siyaleza endaweni yeviwayo of inaliti zeziyobisi. Ngapha koko, nabani na imfihlelo NSAIDs kunokubangela iingxaki ezinkulu esiswini (umzekelo, negalelo ekuveleni izilonda okanye erosions).

Kufuneka kuqatshelwe ukuba izigulane ezininzi ingakumbi emehlweni izixhobo ingxelo ngexabiso. Xa kucingwa ukuba kuyimfuneko ukuthatha ngexesha elinye, kwaye kwixesha elifutshane, a blister kunye iipilisi kunokuba ngokwaneleyo kangangethuba ixesha elide. Kukwasebenza kwanjalo kuyo kwifom injectable olufanelekileyo lwechiza.