"Metoprolol": ncomo, kubonakala ukuba ukusetyenziswa, imfundiso kunye analogue

Kutheni kufuneka iyeza "Metoprolol"? Baqinisekiswa yale yokulungiselela, iifomu ukukhululwa, ukwakheka, kunye neziphumo zalo zithiwe thaca apha ngasezantsi. Siya kunixelela nengcebiso yokuba zeziphi na contra-ezibonisa kunye neziyobisi, oko ulapha kufuneka kuthathwe xa kukho ezinye analogue.

Ukubunjwa ichiza kunye neefom yayo ukukhululwa

Ziziphi fomu ithengiswe amayeza "Metoprolol"? Baqinisekiswa bathi ekhemesti inokufumaneka iindidi ezintathu ichiza. Cinga umba ifomu kunye nesakhiwo ngokweenkcukacha ezingakumbi.

• Amacwecwe. Iqulathe icandelo esebenzayo ezifana metoprolol tartrate (100, 50 no-25 milligrams). Ukongeza, le medicament iquka la macandelo abangabancedani kunye dust anhydrous colloidal, neselulosi microcrystalline, sodium carboxymethylstarch (uhlobo A) kunye wemagniziyam stearate. Ekuthengisweni medicament wafumana amacwecwe-50, 10, 30, 20 okanye 40 pack nganye.
• Iipilisi ngempahla ezinzileyo ukukhululwa ( "metoprolol succinate") amacwecwe camera. Bona inezinto efanayo iyasebenza excipients. Ezikhemisti amayeza inokufumaneka yi amacwecwe 30, 20 okanye 10 pack nganye.
• Ewiliko for kwizitofu emthanjeni xa ampoules of ml-5. Xa intengiso beziyobisi uyangena kwibhokisi ibhokisi ezineengqayi-10.

Iimpawu amayeza ye ichiza

Yintoni ukuthini amayeza "Metoprolol"? Iimpawu zibonisa ukuba ukusetyenziswa zesixhobo ziza thaca ngezantsi. Ngoku ndifuna ukukuxelela ngalokho iipropati amayeza olufanelekileyo lwechiza.

Wathi iyeza ulilungu blocker beta-adrenergic cardioselective. Akunamsebenzi ukubonisa iipropati inwebu ekuzinziseni akukho msebenzi sympathomimetic yangaphakathi. Noko ke, ichiza esebenzayo i umfutho, antiarrhythmic kunye nearhente antianginal.

Le medicament unako yokunciphisa nezihlandlo izinga intliziyo yesigulane, ukunciphisa contractility engabalulekanga kunye excitability, kade AV-Uhanjiso nokunciphisa imfuno ioksijini engabalulekanga.

Ngokuqhelekileyo, le umfutho yabonwa kwizigulane kuphela emva kweentsuku ezilishumi elinesine emva kokuba ezithatha ichiza. Le medicament kunciphisa nezihlandlo nokuhlasela tachycardia supraventricular, angina sifuba kunye fibrillation atrial. Ngenxa yoko, eqhelekileyo intliziyo isingqi malunga nesigulane eso.

Iipilisi kunye ukukhululwa ezilibazisekileyo ( "metoprolol succinate") unokuzuza ebalulekileyo phezu oluqhelekileyo. Amvumela ukuba ukugcina yoxinaniso lomgadi element esebenzayo egazini, ngaloo ndlela kubonelelwa nemiphumo enyangayo elungileyo imini yonke. Kufuneka kuqwalaselwe ukuba isenzo "Metoprolol succinate" kunceda ekunciphiseni ubungozi bradycardia yaye ubuthathaka, ukusa kumkhamo sincinane, ichaphazela izihlunu kakuhle bronchi.

Pharmacokinetics (edalwayo, ukutya kunye kukhuthaza ichiza)

Malunga ezibonisa ukuba ukusetyenziswa lekarstvai "Metoprolol" analogue ezikhoyo iziyobisi uchaze ngezantsi, kodwa ngoku makhe sithethe iimpawu pharmacokinetic.

Oku kuthetha ngokukhawuleza kakhulu kwaye phantse ngokupheleleyo (malunga nama-95%) ako. Ubuninzi plasma xi idla kufikelelwe emva kwemizuzu 50-110 emva kokungenisa.

Isicelo lokuqala bioavailability isiyobisi-50%. Wasiphinda kwandisa kwi-70%. Hi ndlela leyi, ukusetyenziswa ukutya kwandisa bioavailability beziyobisi nge 20-40%. kwakhona kwandisa ukuba ogulayo kwesibindi ukuqina. Unxibelelwano kwiiproteni avareji-10%.

Uthe kakuhle medicament ingena placental kunye nezithintelo segazi lobuchopho. Kwakhona hi mpimo lowutsongo, sime phandle ukuya ubisi lwebele.

Ichiza umzimba esibindini. Kunye metabolites babe umsebenzi imithi. Malunga ne-5% of the uMmeli idubule yi izintso ingatshintshanga. Therapy Nomonde nge function sezintso yancitshiswa kufuna unciphiso okanye enye idosi ulungiso. Noko ke, yokuphazamiseka umsebenzi isibindi bazakucotha yokucolwa iziyobisi. Kulo mzekelo, idosi kufuneka incitshiswe.

Amayeza "Metoprolol": zikhombisa ukuba ukusetyenziswa

Kukho kakhulu uluhlu elikhulu iimeko zophendlo lwezifo apho ichiza iphethwe. Makhe sihlole kubo.

• akathisia, nto leyo ebangelwa antipsychotics;
• umfutho wegazi we-1 kunye nezinga-2 umfutho wegazi (mhlawumbi monotherapy, yaye kwiimeko ezinzima - kunye womchamo kunye namanye amachiza umfutho);
• thyrotoxicosis (nje inxalenye yonyango leqela);
• ukuthintelwa lokuhlaselwa angina kunye angina;
• prophylaxis of migraine;
• kophulwa umthetho isingqisho kwentliziyo (umz, arrhythmia, kwaye paroxysmal tachycardia supraventricular, tachycardia supraventricular);
• ukucutha umngcipheko sabantu nokudodobala isifo sentliziyo kunye nesifo kwemithambo;
• secondary ukuthintelwa iposi engabalulekanga kunye iqhosha elibukhali engabalulekanga;
• prolapse valve mitral;
• cardiomyopathy inimba is idiopathic;
• giperkinez senhliziyo Essential, hyperkinetic kwentliziyo syndrome, ukuphazamiseka yentliziyo.

Izimvo medicament

Ngokutsho ncomo abo wakha wabhekisela ichiza, ngokuphumelelayo ukumelana umsebenzi kunye nempembelelo entle entliziyweni. Nakuba kunjalo, kufanele kuqatshelwe ukuba ezinye izigulane basabela ogqirha azikho kakuhle kakhulu. Njengomgaqo, oku kungenxa yokuba iye Izimo ezininzi kunye neziphumo ebezingalindelekanga. Inyaniso yokuba, kuzo izigulane akhalaze, chaza ngezantsi phezu zithe zafunyanwa iimali ezo.

Izimo ukusetyenziswa iyeza

Ngoko ke, ngoku uyazi ukuba kuthetha ukuthini iziyobisi "Metoprolol" (ezibonisa zokusetyenziswa ziye kuchazwa nje ngentla). Nangona kunjalo, eli chiza eziliqela Izimo. Ezi ziquka:

• ukunyamezelana ngamnye (ngamanye hypersensitivity amacandelo esebenzayo okanye abangabancedani);
• block we2 atrioventricular lwesifo 3;
• ukusetyenziswa kwexesha elinye-nge Mao inhibitor;
• ukuvimba sinuauricular;
• wavakalisa izifo yegazi (peripheral);
• sinus bradycardia (umyinge intliziyo ukuba - ubuncinane amathandathu ngomzuzu);
• hypoglycemia kunye nefomu labile seswekile;
• syndrome sinus ogulayo;
• isigulane kubuphepha bronchospasm (ngamanye amazwi, isifuba inyumoniya kunye nempendulo inyumoniya kakhulu);
• lactic metabolic;
• hypotension (ngaphantsi kwe-100 mm HG ..);
• mothuko cardiogenic (ichiza akukhuthazwa ukuba izigulane kunye lokufunyaniswa "iposi engabalulekanga etsolo" okanye ekurhanelwa ukuba kuyo);
• ukusilela etsolo intliziyo, ezinganyangekiyo (isigaba 2 and 3) kunye uncompensated.

Izithintelo kusetyenziso ichiza (reception ngononophelo okukhulu)

Ziziphi iimeko kufuneka libekelwe umda ekufumaneni "Metoprolol 'iziyobisi? Iingcali Ukubuyekezwa zithi umthamo we medicament ukuba zibhalwe hyperthyroidism, emphysema, imbali negazi, isifuba inyumoniya, iphika non-kukwalisa, ukhwekhwe, pheochromocytoma, iingxaki zesibindi, sezintso (ngamanye amaxesha), udandatheko, myasthenia gravis kunye Ukubulawa jikelele.

Ngaba kunokwenzeka ukuba ukunika abantwana amayeza "Metoprolol"? Ukusetyenziswa kwale iyeza ngabantu abangaphantsi kweminyaka eli-18 ubudala akuvumelekanga. A ban Beyamkele imali efikelela abasetyhini abakhulelweyo kunye noomama zokonga. Ukungaphumeleli ukuthobela ezi ngcebiso, kukho umngcipheko omkhulu bradycardia, hypoglycemia, kunye hypotension kwi usana olusanda kuzalwa.

Ukuba ufuna idosi amayeza ngexesha lokuncancisa, kweli xesha lokwaphusa kufuneka kupheliswa.

Iziyobisi "Metoprolol" yaye "Metoprolol succinate": imiyalelo yokusebenzisa

Ngokuqhelekileyo, le medicament "metoprolol" athathe usuku isixa 100 mg. Lapho wathi lesixa yahlulwe amathamo eziliqela. Ukuze kufikelelwe isiphumo ilungileyo kwezonyango, ulwamkelo angandiswa ngu 2 umphinda-. Noko ke, ukuba idosi iphezulu ichiza kufuneka mayingagqithi 400 mg.

Xa ixesha elinye-inaliti efakwa maliqhutywe ukuqalela mg-2 ukuya ku-5 yokulungiselela. Kulo mzekelo, idosi iphezulu ngu 15-20 mg. Xa kungekho yifuna bavunyelwa ukuba baphinde bangene iyeza ichiza (kwimizuzu-5).

Rhoxisa ukuqeshwa ichiza kufuneka ngokuthe ngcembe. Ngokuqhelekileyo oku kwenziwa iintsuku ezilishumi phantsi kweliso ezizodwa kagqirha.

umthamo lokuqala ichiza "metoprolol succinate" kunye tachycardia supraventricular, sifuba angina, arrythmia kunye noxinzelelo lwegazi imalunga 50-100 mg kanye ngemini. Xa ulondolozo therapy of iposi engabalulekanga abafumana medicament xa umthamo we mg 200.

Ubude ubuncinane unyango lithetha "metoprolol succinate" na iinyanga ezi-3. Ukuba isigulane unesifo sisifo sentliziyo esinganyangekiyo, idosi yoxhaso ngamnye. Okokuqala, ichiza ezibanjiswe mali ka-12.5 mg kanye yonke imihla iiveki ezi-2, yaye ke ngoko zonke iintsuku ezili-14, kabini idosi.

Xa ukunyamezelana kahle ye medicament ukutya kwayo liphezulu ngosuku ukufikelela mg 200.

imiphumela emibi. baqinisekiswa

It banokubenzakalisa amayeza umzimba "Metoprolol"? Izimvo yale yokulungiselela iqulethe ingcaciso eninzi ukuba emva kokungeniswa kukho imiphumo emibi. Malunga apho izenzakalo umbuzo?

• Ukususela luvo: buthathaka kwezihlunu, ukudinwa, amabi, ukudakumba, intloko ebuhlungu, ixhala, sehlise kweemoto nezengqondo reactions, sinciphise ingqalelo, paresthesia kwi yesiqephu, memory lomonakalo elifutshane elide, ukozela okanye, icala, ugwayi.
• Ukususela mvo: kuncitshiswa secretion kolwelo iinyembezi, sinciphise umbono, conjunctivitis, iintlungu kunye imifinya owomileyo kwiinwebu yamehlo, ikhalisa ezindlebeni.
• inkqubo Cardio-nemithambo: arrhythmia, sinus bradycardia, angina lobuxoki, Uhanjiso ukuphazamiseka iqhosha, bemthoba uxinzelelo lwegazi, kubonisa vasospasm, hypotension intolerance, sinciphise contractility engabalulekanga kunye nesiyezi.
• Kwinkqubo yokwetyisa: umlomo owomileyo, iintlungu esiswini, isicaphucaphu, umsebenzi isibindi okungaqhelekanga, ukuqhina, ukugabha, urhudo, kunye notshintsho incasa.
• Yesikhumba: ukurhawuzelela, alopecia ingathityazwa, irhashalala, ukuhlisa, irhashalala, ukubila, exacerbation of ukhwekhwe, photodermatosis, exanthema nesikhumba psoriasiform ngayo.
• isixokelelwano sokuphefumla: ukuphelelwa umoya, ukuxinana ngeempumlo, bronchospasm kunye nobunzima kuphela.
• Ngomhla inxalenye yenkqubo yonyango: hypothyroidism, hypoglycemia kunye hyperglycemia.
• Tests zeLebhu: thrombocytopenia, agranulocytosis, hyperbilirubinemia, leukopenia, kanye enzyme zesibindi ephakamileyo.
• Ifuthe ekukhuleni kosana olungekazalwa yomfazi okhulelweyo phantsi isicelo: intrauterine abazizidalwa ngokukhula, bradycardia kunye hypoglycemia.

Ukongeza, emva kokufumana iziyobisi bathi ezinye izigulane ingxelo kukuvela intlungu ezidityanelweyo okanye iqolo. Ezinqabe kakhulu ibonisa abantu ukuba baye ubunzima bomzimba linyuke kancinane, sinciphise yobuntu okanye amandla.

isikhokelo ethile ngokusetyenziswa ichiza

Ke kaloku, ngazo naziphi na ekhemesti unako ukuthenga ichiza "Metoprolol". Iresiphi ingafuneki. Noko ke, ngokuba izigulane ngokuthatha amayeza kufuneka rhoqo esweni ugqirha okunyangayo. Oku kuyinyaniso ingakumbi kwabo izigulane abafunyenwe seswekile okanye angina.

Kuye siyazi ukuba ngokwandisa idosi (ngaphezu kwama-200 mg ngosuku) kunciphisa cardioselective. Phambi unyango ukusilela intliziyo iqalwa kuphela emva kweqonga imbuyekezo sifikelelwe.

Abantu abasebenzisa lenses, kufuneka siqwalasele ukuba kwimeko unyango, "metoprolol" kuncitshiswa imveliso lachrymal fluid.

Ngamanye amaxesha le amayeza kugqiba ezinye iimpawu hyperthyroidism. Kule ukurhoxiswa ngokukhawuleza beziyobisi izigulane kunye nesifo kuthethwa contraindicated, ekubeni iphucula iimpawu.

Ukuba kuyimfuneko, umsebenzi isigulane kufuneka kusoloko tufwile anesthesiologist kuthomalaliso iziyobisi.

Ngexesha unyango, ichiza, "metoprolol" kuyimfuneko ukunxiba iimpahla ezifanelekileyo. Oku kungenxa yokuba ichiza kunokubangela kukwalisa ulusu ngenxa elangeni.

Asinako ukuba iyeza "Metoprolol" (analogue iyeza ingakumbi) kwi abalupheleyo kunokubangela ukubonakala bradycardia okwandayo, ephawulwe ukuncipha uxinzelelo lwegazi, ibhloko atrioventricular. Kungenxa yoko le izigulane kufuna ulawulo olulodwa.

Ukongeza, ngexesha unyango kunye eli chiza kufuneka ayiyeke lokuqhuba isithuthi kwaye uyeke iiklasi izinto eziyingozi ezifuna yoxinaniso ophezulu kunye reactions isantya lengqondo. Kukwacetyiswa kwakhona ukuba ukwamkelwa ethanol.

Akhona analogs iziyobisi

Kuthekani ukuba isigulane akakwazi ukuthenga amayeza amiselwe ngugqirha, 'metoprolol "? analogue ezifumaneka kuyo nayiphi ekhemesti. Abaninzi kubo ziqulathe into esebenzayo efanayo, ngoko ngayo iimpawu ezifanayo njengoko watshoyo iziyobisi. Phakathi kwezi ukuze kuchazwe amachiza zilandelayo: "Metoprolol Acre", "Metolol", "Metokor Adifarm" kunye nabanye.

Emva yokufumana ugcino-lwazi kuthetha ukuba isigulana bacetyiswe ukuba libhekisela imiyalelo, kwaye ukuba ubonane nogqirha. Oku kungenxa yokuba indlela abafumana zingohluka kwezo iidosi ngentla iindlela.

Yintoni enye oku amayeza analogs? Faka ugqirha zobu bekwa kuba amayeza ilandelayo: "bisoprolol" "Metoprolol-ratiopharm", "Metokard", "Korvitol", "Metozok", "Lidalok", "Serdol", "Egilok", "Emzok" kunye nabanye.

Indlela ukugcina namayeza kangakanani?

Ke kaloku, ukuba uyazi ukuba yintoni na, ukuba ayinonophele njani kwaye yintoni idosi amayeza "Metoprolol". Sikugcine kwindawo epholileyo (umz, kwifriji) okanye igumbi apho lobushushu awudluli degrees 25. Kulo mzekelo, ichiza kufuneka ukhuselwe elangeni ngqo.

Ubude bethuba ubomi iziyobisi bathi kwaye uninzi osi iminyaka emihlanu ukususela kumhla kwimveliso. Emva kweli xesha, amayeza asetyenziswa iinjongo zonyango kunye umbala akuvumelekanga. Kufuneka zilahlwe.