Ichiza "Ursodez" - imiyalelo ukusetyenziswa. Tablets "Ursodez": analogs kunye nohlaziyo

Drug "Ursodez" - iziyobisi hepatoprotective. Kuye medicament choleretic, hypolipidemic, inyathelo holeliticheskoe, anazo hypocholesterolemic nesiphumo immunomodulating okungenamsebenzi. into esbnzyo - ursodeoxycholic acid. Eli chiza akukho uhlobo idosi "iipilisi". "Ursodez" evela ngokohlobo njengezingxobo.

mechanism umsebenzi

I engekho mthethweni esebenzayo uyakwazi kudityaniswa inwebu of hepatocytes, ozinzileyo isakhiwo sayo. Ngenxa yoko, iiseli akhuselwe ukusuka izinto ephazamisayo, umsebenzi iityuwa inyongo acid. Isiphumo therapeutic beziyobisi babonakaliswa ngaloo ekwehliseni isiphumo cytotoxic. Ngokuchasene imvelaphi cholestasis isebenze Ca2 + protease oxhomekeke exocytosis alpha-kwavusa. Lithetha "Ursodez" (application User ibonisa oko) kunciphisa kakhulu asidi inyongo ityhefu (deoxycholic, lithocholic, chenodeoxycholic kunye nabanye) kwi zoqhaphelo ephakamileyo izigulane ezimbi hepatic ekuhambeni ezigulo ezondeleyo.

Xa ukufumana amayeza ophawulwe ukuncipha cholesterol amagama kunye secretion, inhibition of kukufakwa yayo emathunjini. Ngenxa oku, oko kusehla Ukwanda inyongo nale ezimbaxa. Amalungiselelo uyakwazi ukunciphisa inokhuphiswano absorbability ye asidi lipophilic apha emathunjini, ukwanda iqhezu umhlaba turnover ekujikelezeni kwazo enterohepatic. Amayeza lukwakhuthaza kukhuthaza asidi zinetyhefu, ukwanda sicatshulwa.

Indlela yokusebenza ye ichiza nayo isekelwe ukuhluza asidi inyongo nonpolar. Ngenxa yale micelles enetyhefu mixed. Kuthetha mandla kwinkqubo biliary, ukunyibilika cholesterol, uzinzise imveliso kunye secretion of inyongo. Ichiza kunciphisa lithogenicity yayo, kwandisa lwee- asidi, ngaloo ndlela Nokumphikisa ukwanda umsebenzi secretion pancreatic kunye esiswini.

Xa abafumana iipilisi waba ukupheliswa ngokupheleleyo okanye olungaphelelanga ngamatye. Ngokunciphisa enyongweni cholesterol Ukwanda eyomeleziweyo ngokugaya samatye. umsebenzi Immunomodulatory ke oluboniswe ngenxa azinampembelelo basabela ezichaphazelekayo sisibindi. Ichiza kunciphisa ibinzana elithi iqela awakwazi histocompatibility. Le medicament onesiphumo kwinqanaba T-lymphocyte, kunciphise inani eosinophils.

Pharmacokinetics kuthetha

Kukufakwa ichiza "Ursodez" (umyalelo manual ibonisa oku) apha emathunjini amancinci eyenziwa inkqubo kwe- kwisixando sokwenziwa. Kufunxwa ne-90% ye-component esebenzayo. Xa ileum iziyobisi ifunxwe ngezithuthi esebenzayo. Umxholo liphezulu candelo esebenzayo ifikelela malunga enye iyure. Umchiza inepesenti ophezulu kwiproteni ziyabophelela - 99%. Ursodeoxycholic acid uyakwazi ndzulu ngumkhaya.

Ukusebenza therapeutic beziyobisi kuxhomekeke uyondelelwano lwee- esisebenza enyongweni. Njalo ngendlela ukwamkelwa le acid inyongo kuba serum zaseprayimari. ursodeoxycholic acid xi yi malunga ne-48%.

Umchiza umzimba, udlula iiseli zesibindi. Ngenxa yoko, kwasekwa glycine kunye taurine conjugates. Iimveliso ukubola ke secreted zibe inyongo. Malunga 50-70% efunyenweyo ichiza kwizondlo endleni. Umthamo omncinane ichiza ihanjiswa kulo ngekhefu. Apho ke ahlukana yi sisenzo iintsholongwane (7-dehydroxylation).

Lithocholic acid, oluthi luqokelelane yile nkqubo, ufakwa onokufunxa kwenxenye ye Amathumbu amakhulu, kodwa udlula sulfation esibindini kwaye idubule njengoko sulfolitoholiltaurinovogo okanye udibaniso sulfolitoholilglitsinovogo.

ubungqina

Medicine "Ursodez" kucetyiswa kwanonyango kwangumqondiso ukuba kwesibindi ephambili biliary ngaphandle imiqondiso decompensation. Ukubonisa yindlela wavala eliphakathi kunye amatye cholesterol encinane, kunye senyongo esebenzayo. Prescribers nge biliary reflux gastritis.

Izimo

Lithetha "Ursodez" umyalelo kwi isicelo awuvumeli ukuya kuyo ukuba amacandelo esi rentgenpolozhitelnyh izigulana (i xi eziphakamileyo Ca2 +) enyongweni ukunganyamezelani medicament. Izimo ziquka ukuqina kwinyathelo decompensation ivakalise ukuphazamiseka zepancreas, zezintso. iziyobisi okunikezelwe abantu kunye neendawo isinyi inyongo, ezimbi zosulele yokukrala indalo yayo, kwakunye nesifo kwesisu kunye inyongo duct. Musa ukumisela amayeza kwabakhulelweyo kunye nabongi. Kuthethwa contraindicated abantu abadala kunye nabantwana abanobunzima ngaphantsi kwama-34 kg.

imiphumela emibi

Kwezinye iimeko, ukuphuhlisa iziphumo okungafunwayo ngexesha uthatha ichiza, "Ursodez". Imiyalelo yokusebenzisa zilumkisa ithuba isicaphucaphu, urhudo, ukugabha. Xa unyango komhlaba i bangaba enyongweni calcified. Yokukhulisa umsebenzi kwesibindi transaminase, iintlungu esiswini, negazi (kubandakanywa urticaria) nazo ungayiboni imiphumo kokungenisa "Ursodez".

Baqinisekiswa kubonisa tolerability elungileyo. Ngokuxhomekeke kwiziphumo kwimigqaliselo kwicala kagqirha amathuba. Kwezinye iimeko, ngexesha unyango kwesibindi biliary waphawula decompensation idlule. Ngokuqhelekileyo, le nto yodwa nothi emva ukupheliswa ichiza.

Drug "Ursodez". Price. umyalelo

Kuthetha ukuthatha ngokuhlwa. Esithathwa yemihla ngemihla ezinyibilikayo amatye - umlinganiselo 10 mg / kg. Kuba abantu ezinobunzima ukuya kwi-60 kg siyafana njengezingxobo 2nd ngosuku ukuya 81 kg- 3-m, 100 kg - 4 ngaphezulu 100 - 5. Ubude - ukusuka kwiinyanga ezintandathu ukuya kwiinyanga ezili-12. Emva ezinyibilikayo namatye ukuthintela ukuyilwa lwamkelo ecetyiswayo ezinye iinyanga eziliqela.

Treatment kwesibindi biliary wenziwe ithamo ka 250 mg / ngosuku. Lokuqhubeka kwekhosi - iintsuku 10-14. ukuya kwiinyanga ezintandathu. Kwezinye iimeko, ubude uthomalaliso landile ukuya kwiminyaka emibini. Njengonyango kwangumqondiso medicament elawulwa 10-15 mg / ngosuku. Xa ubunzima ukuya ku-34 kg ezicetyiswayo lithetha ifomu lunqunyanyisiwe. Iindleko beziyobisi ifomu philisi - ukusuka nekhulu engange.

Ikwenza oko kuthetha "Ursodez" nabalingani?

Iziyobisi eziqulathe ukwimo enye esebenzayo, wavelisa kakhulu lukhulu. Phakathi kwabo kufanelekile ukuba sikhankanye iindlela ezifana "Ursodoksa", "Ursol". Enye kakhulu ethandwayo ichiza "Ursosan". Iimpawu zibonisa ukuba ukusetyenziswa kweziyobisi thile ngokubanzi. Ngokukodwa, oko ibhalwa esinganyangekiyo abanesigulo zesibindi skleroziluyuschem cholangitis uhlobo ezigulo ezondeleyo.

Izigulane ezininzi banomdla ukulungiselela into engcono "Ursodez" okanye "Ursosan". Kufuneka wathi ugqirha ukhetha enye okanye ezinye iindlela ngokungqinelana uhlobo, ikhondo leengxaki kunye isigulane wabunyamezela ichiza. Xa izifo ophezu kwesibindi, senyongo akukho kakhulu kucetyiswa self. Ngaphambi ukuthatha nawaphi na amayeza kufuneka zeemviwo kokubonisana yincutshe.

Ukubeka iliso impumelelo unyango kufuneka qho kwiinyanga ezi-6 wenziwe. Kule uxhulumaniso kokuba unikwe ultrasound rhoqo kunye noviwo X-ray kunyaka wokuqala zonyango. Ukuba kwiinyanga zokuqala ezintandathu wokupheliswa amatye zange yenzeke, kungenzeka phambili kule khosi nzima ngenxa nokungasebenzi.

ulwazi olongezelelweyo

Ukuqinisekisa ukuchithwa ngempumelelo yamatye kuyimfuneko ukuba matye cholesterol kuphela, kodwa ubungakanani ayidluli milimitha-15 okanye 20. Ngelo efanayo ixesha ezaliswe esinyini nenyongo kufuneka abe ngaphezulu kwesiqingatha, kwaye iphecana biliary sibe ngokupheleleyo umsebenzi wayo.

Kwimeko apho elide unyango, ngaphezulu kwenyanga, kuyimfuneko ukwenza kulingwa zengqo- yokuvavanya umsebenzi transaminases esibindini. Ngaphezulu, kufuneka ukulawula uyondelelwano lwee- yibilirubin kunye nezinye kusitsha. ukuziyeka "Ursodez" lithetha lo gama kugcinwe ukusebenza eliphezulu. Izimvo ziingcali ezininzi, ke, ezincomekayo malunga ukusebenza beziyobisi.

isiphelo

Ukuba akukho japan linokukwenziwa kwenye medicament okanye qhinga unyango ehlaziyiweyo ngokupheleleyo. Ngaphambi usebenzisa imveliso kufuneka babenolwazi ukuvula.