Hyperandrogenism ku abafazi: ebangela, iimpawu, unyango. Le hyperandrogenism eyingozi kwabasetyhini

Xa iyeza, ingxaki eyaziwa ngokuba hyperandrogenism kwabasetyhini. Oonobangela, iimpawu, unyango unesifo onjalo kufuna uvavanyo kunye inxaxheba oogqirha abafanelekayo. Nangona esi sifo kunzima kakhulu soyise ngokupheleleyo, vula koogqirha ngcono ngaphandle kokulibazisa.

Kakuhle eli sifo

Xa kufikelelwa kwesi sifo njengoko hyperandrogenism kwabasetyhini, ebangela iimpawu, unyango kunye amanyathelo othintelo asoloko ezinxulumene ingxaki enjalo, njengoko ifuthe adrogenov emzimbeni. Le nkqubo ikhokelela ukubonakala imbonakalo noyinkazana iimpawu oyindoda, kunye nezinye utshintsho mnandi kangaka. Xa iinkcukacha ngakumbi, sithetha izinto ezinjalo ngokubonakala iinwele zobuso neenwele umzimba, ilizwi enzulu, yaye litshintsha ezinye mzobo lweziqalelo.

Kubalulekile ukuphawula ukuba i-ngezifo inkqubo yonyango ababhinqileyo kuqhelekile, kwaye akakwazi kukhokelela kuphela utshintsho ezingemnandi yangaphandle, kodwa nezinokubangela ubudlolo. Ngoko ke, xa iimpawu zokuqala hyperandrogenism, kufuneka ngoko nangoko ukuhlela utyelelo kugqirha.

Kutheni ukuphuhlisa ngezifo

Komxholo othi "hyperandrogenism amabhinqa: ebangela iimpawu,» unyango Kubaluleke kakhulu besini intle, kuba le ngxaki siboniswa nama-20% yezigulane. Ngoko yenza ingqiqo ukuze sinikele ingqalelo imiba kunye neenkqubo ezikhokelela kuphuhliso kwesi sifo.

Esona sizathu icaciswa AGS - adrenogenital syndrome. Undoqo kukuba adrenal bayakwazi ukuvelisa ezinye hormone, ukongeza adrogenov, ezifana glucocorticoids. Le yokugqibela kuvela phantsi kweempembelelo enzayim ethile. Isiseko ukwenzeka yabo ababeyiqwebile androgens. Ngamanye amaxesha abasetyhini sele akhoyo ekuzalweni isiphene enzyme, nto leyo a iihomoni oyindoda nje ukuguquka kwaye kuqokelelwa rhoqo, ukuba imzisele utshintsho ezingentle ngomzimba ababhinqileyo.

Kukho nenye inkqubo, leyo iphuhlise ngenxa hyperandrogenism lemvelaphi adrenal. Sithetha yamathumba kwamadlala adrenal. Bona kwakheka kwakhona kwisiqalo ukwanda lamanani androgens.

Umngcipheko sifo okhankanywe ngasentla kubonakala kwimeko xa kukho imveliso hormone eyindoda amaqanda lebhinqa. Ngaphezu koko, iiseli ezivelisa Adrogué kunokubangela ithumba uluhlu zamaqanda.

hyperandrogenism syndrome wambi sisiphumo sesichengeni ezimbi ezidalwe zeminye imibutho, ezifana ingqondo yebhinqa.

Iimpawu obugqithisileyo androgen

Ukuba sithethe ngeempawu lwezonyango zoqhaphelo ephakamileyo hormone eyindoda, ukuba ingachazwa ngolu hlobo lulandelayo:

• izinduna;
• kufe ebunzi iinwele kunye iindawo kungachetywa ntloko (alopecia adrogennaya);

• glands sebaceous avelise izixa ngokugqithiseleyo secretion, onesiphumo olunamafutha ukunyuka eluswini;
• barifoniya ukuba kuthethwa nokubanzulu ilizwi;
• phezu esiswini sakhe neenwele esifubeni kuvela.

Kubalulekile ukuphawula ukuba hirsutism - ukukhula ngokugqithisileyo kweenwele yesiphelo emzimbeni nemazi, banesifo ngo-80% ezigulane kunye nale ngxaki hyperandrogenism syndrome.

Ekubeni sifo kwezinye le intle sex ukuphazamiseka sexesheni, ukungabi sexesheni kunokwenzeka, kwakunye engabalulekanga hypertrophy, ukutyeba, nenzalo, kunye noxinzelelo lwegazi.

Uyondelelwano lwee- iihomoni oyindoda kunokubangela yokukhulisa susceptibility yomzimba nemazi ukuba ungenwe lula zizifo yeentlobo ezahlukeneyo. Kwakhona fatigue kunokwenzeka notyekelo ekudakumbeni.

Induna futhi sebaceous namadlala

Ukuze siyiqonde ngokucacileyo ukuba yintoni ezakwenziwe malunga ngxaki njengoko hyperandrogenism kwabasetyhini, ebangela, iimpawu, unyango, kwaye isifo kufuneka siqwalasele ngocoselelo. Njengoko izinto ezibangela uphuhliso esi sifo, kuxoxiwe ngasentla, iyavakala ukufunda iimpawu iimpawu.

Xa uthinte le ngxaki njengokuba amaqhakuva, kubalulekile ukuqaphela ukuba le zibangelwa keratinization kodonga follicle kunye nemveliso sebum zanda, ekhuthaza androgen boxinzelelo, kuquka plasma. Xa iimpawu ezinjalo zidla COCs emiselweyo okanye antiandrogens, nto leyo evumela kakhulu ngcono imeko yesigulane.

Kwakhona phantsi kweempembelelo hormone eyindoda androgenozavisimyh kwimimandla kuvela ulwehlo, elingqingqwa, ngoboya endaweni vellus. Oku kudla eyenzeka ukufikisa. Kulo mzekelo, ifuthe androgen phezu iintshiyi, amashiya, izahlulo zexeshana kunye Occipital into ezincinci.

hyperandrogenism adrenal

Kubalulekile ukukhumbula ukuba ingaba adrenal - ezi amadlala ezimbini yonyango ukuba iqhele ngaphezu izintso ngokwabo.

Bona umthombo ka-95% eziveliswa androgen (DHEA-sulfate). Ukuntsonkotha hyperandrogenism enxulumene nezi namadlala, amathumba phantsi yokuba leengxaki na iziphene ngokwendalo kwaye yenza ngokwayo waziva kwisiqalo androgenitalnogo syndrome. Oku kukhokelela ekuncipheni kwinqanaba elibalulekileyo kwi-enzayim umzimba nemazi kuyimfuneko ukuvelisa iihomoni ezifana glucocorticoids.

Hyperandrogenism of adrenal imvelaphi oubslovlena ngayo le ngxaki, nto leyo ekhokelela ukunyuka lamanani zezinye - hormone. pregnenolone, dlala, njl zigqityiwe Ezo utshintsho yemveliso nangakumbi androgen emzimbeni ababhinqileyo.

Maxa wambi bene ngezifo, nto leyo ebangelwa yamathumba kwamadlala adrenal avelisa hormone eyindoda. Ngokobalo manani olu hlobo sifo njengoko hyperandrogenism adrenal busisigxina ngo ne30-50% amabhinqa ingxaki androgen.

Impembelelo zamaqanda

Le xi eliphezulu zamadlala inkunzi kuchaphazela ukusebenza zamaqanda. Kwiimeko ezininzi, le ngxaki uzenza wagqogqa iifom ezimbini: gipertekoz kunye polycystic. Kubalulekile ukuba banikele ingqalelo into yokuba ingozi yokuba esi sifo kwabasetyhini kwanda imithambo rhoqo imidlalo ngamandla.

hyperandrogenism Ovarian i ngenxa abazimisele phantsi ukukhula zoboya phantsi kwempembelelo androgens. Ngenxa yezi kwaye zibandakanya amaqanda, i ngenxa yeenkqubo ezinjalo uba elidlulileyo imperforate. Igama lonyango le ngxaki - atresia follicular.

Kodwa asingabo bonke ubunzima eziyelelene ovarian hyperandrogenism genesis. Eyona nto ibalulekileyo kukuba hormone inkunzi usebenza njengomba ngawo iphuhlise ukwakheka okungaqhelekanga kwithishyu ezinezikhondo nokuqina, nto leyo ekhokelela polycystic. Kulo meko, iindaba ezimnandi kukuba ingxaki efanayo ejongene% 5 kuphela abasetyhini.

Kananjalo kubalulekile ukuba siqaphele ukuba olu hlobo hyperandrogenism, besini wamhle na unobangela ukungaphumeleli ezingummiselo engundoqo amanqanaba androgen. Le nkqubo ithatha indawo kwinqanaba le ngxenye kunye yebhinqa. Ngenxa yeenguqu hormone kakhulu.

Miqondiso uyenzayo wena, ukuba unikele ingqalelo

Kukho inani kweempawu ezibonisa isenzeko le ngxaki zichazwe ngentla. Into yokuba kufuneka sibe ezifana ngezifo of ovarian imvelaphi hyperandrogenism, lungafumaneka kwi wabonakala zilandelayo:

• kwamathambo;
• seborrhea;
• phezu kobuso, ukongeza amaqhakuva, kukho ukuxobuka kunye nangokurhala, ezo kunzima Nokwethisa iindlela ukusoloko cosmetology;
• yoma imisipha;
• ukutyeba;
• ukutshintsha olinganise umzimba nemazi - masculinization;
• nokubanzulu voice (barifoniya);
• kukhule uboya wonke umzimba, nkqu nokuba sele sijamelene;
• ukuyilwa mpandla entlokweni.

Ukongeza, kukho iimpawu ezininzi zasesekondari, ezifana kumanqanaba igazi iswekile, umfutho wegazi, kunciphise sifo, kunye nabanye.

umzimba

Ukutyeba kwabasetyhini kunokubangela hyperandrogenism ovarian ezichazwe ngasentla. Kule fomu ye sifo isoloko ezisisigxina ukhulisa estradiol.

isifundo Medical lwenziwa, njengoko apho ukuqinisekisa le ngcaciso ilandelayo: indlela phezulu amanqanaba hormone eyindoda, yaye phantsi kwempembelelo sayo estrogen kuba nefuthe ngqo kuphuhliso lwe ukutyeba, ehambelana uhlobo eyindoda.

Ezi nkqubo unobangela insulin-oxhomekeke yokukhulisa okuzikisa kweziveliso ze-hormone lokukhula umzimba abafazi iinkunzi abaneengxaki ezichazwe ngasentla. Kwezinye iimeko, androgens kuchaphazela amabhinqa hayi awayebhitye kakhulu kwisixokelelwano luvo.

ifomu ingxubevange

Oogqirha ngamathuba rhoqo kufuneka ukujongana iintlobo eziliqela kubonisa hyperandrogenism. Le meko ichazwe yi kukuba ngelo xesha kukho ulwaphulo-mthetho wemisebenzi adrenal kunye ovarian.

Ukuba nokwenzeka iingxaki ezinjalo kubalulekile ukuba siqwalasele kuphononongo oko hyperandrogenism oluyingozi kwabasetyhini. Enyanisweni, oku kwenzeka: androgens adrenal, zigxile kwi adrenal, oko kukhuthaza inqanaba hormone eyindoda zamaqanda. Le nkqubo lwenzeka egazini, nto leyo ekhokelela ekunyukeni imveliso luteinizing hormone. Le yokugqibela, nayo, kuphakamisa ukubonakala hyperandrogenism syndrome.

Ukwenzeka Iifomu ugalelwe leengxaki ekunokuthiwa umothuko kakhulu, ukunxila ubuchopho okanye ithumba yebhinqa.

ekuxilongweni

Ekuqaleni, ugqirha kufuneka ohlulwe kwabanye izifo hyperandrogenic apho yenzeka (acromegaly, Cushing engqondweni, izifo zesibindi kunye nabanye.). Inyathelo elilandelayo ukumisela amanqanaba hormone. Le nkqubo kufuneka yenziwe ungatyanga kusasa. Uhlalutyo olunjalo kufuneka enze izihlandlo ezithathu njengoko iihomoni kunye androgen high xi esoloko itshintsha.

Kucelwa nithathele ingqalelo le kwinqanaba dehydroepiandrosterone, imixholo eliphezulu eya kuba bubungqina hyperandrogenism adrenal. Kwakhona kubalulekile kwaye neqondo ketosteroids Umchamo. Ukuba umxholo ingaphandle kuyinto eqhelekileyo, iyavakala orhanela kuphuhliso ngezifo.

ayini

Hyperandrogenism - oku sisikhulu kakhulu imbambano ngoyaba uncedo booogqirha abafanelekayo. Kwaye xa sihlalutya ikhondo unyango, kunokwenziwa isigqibo ukuba ijoliswe ekufezekiseni iinjongo ezine eziphambili:

• obubonakala zokususwa kwesikhumba;
• kuqheleke ukuba sexesheni;
• unyango lwe nenzalo, leyo okubangelwa anovulation;
• ukupheliswa kunye nokuthintela izifo pathways ezinxulumene isifo ephambili.

Diet for hyperandrogenism kwabasetyhini umiselwa kwimeko ukwanda nobunzima kakhulu. Kulo mzekelo, kubalulekile ukulandela ngqo zonke iingcebiso ugqirha, kuphela phantsi kwalo mqathango, ungafumana iziphumo ekunene.

Abo izigulane Niza kuba nomntwana, kwiimeko ezininzi, amisele unyango hormone oluya kwenza ukuba kuphuculeke ovulation epheleleyo.

Abasetyhini abo uceba ukukhulelwa, baye unyango, kuquka izivimbela, kwaye kwezinye iimeko, ovarian alubi resection.

Amalungiselelo yonyango hyperandrogenism kwabasetyhini kwakhona isetyenziswa ngokubonakalayo, ukuba umzimba akakwazi Nokwethisa namanqanaba aphezulu androgen yedwa. Sithetha izixhobo ezifana "metipred" "Dexamethasone", kunye nabanye. Utyando uya kunyanzeliswa apho kwadala ngezifo ithumba.

iziphumo

Le xi eliphezulu zamadlala eyindoda emzimbeni female - ungaphezulu kwe ingxaki enzulu kaninzi ukuvela imvelaphi akukho zifo ngaphantsi yingozi. Ngoko ke, xa kuqala iimpawu afunyaniswe isifo kwaye afumane unyango kufuneka wenziwe nakanjani.